iPTMnet Report for Q13873 (BMPR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13873 / BMPR2_HUMAN
Protein Name Bone morphogenetic protein receptor type-2 precursor
Gene Name Name: BMPR2
Synonyms:PPH1;
Organism Homo sapiens (Human)

PRO ID PR:Q13873
DAG View
PRO Name bone morphogenetic protein receptor type-2 (human)
Definition A BMP receptor type-2 that is encoded in the genome of human.
Short Label hBMPR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13873 (BMPR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N55 N-Glycosylation GlyGen 29741879, 24190977
T137 O-Glycosylation GlyGen 30459171
K219 Acetylation PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
Y314 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus   UniProt 19369195
S513 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
Y546 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
Y551 Phosphorylation PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus
T575 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus   UniProt 18691976
Y589 Phosphorylation PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
Y708 Phosphorylation PhosphoSitePlus
S757 Phosphorylation phospho.ELM   PhosphoSitePlus 16155937
K763 Ubiquitination PhosphoSitePlus
T803 Phosphorylation PhosphoSitePlus
T805 O-Glycosylation GlyGen 28657654
T805 Phosphorylation PhosphoSitePlus
Y825 Phosphorylation PhosphoSitePlus
N827 N-Glycosylation GlyGen 29671580
S862 Phosphorylation PhosphoSitePlus
S863 Phosphorylation PhosphoSitePlus
C910 Methylation IEDB 31844290
T977 Phosphorylation PhosphoSitePlus
Y979 Phosphorylation PhosphoSitePlus
S980 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S513 Phosphorylation HPRD 18691976
S586 Phosphorylation HPRD 18691976
S680 Phosphorylation HPRD 18691976
S681 Phosphorylation HPRD 18691976
S757 Phosphorylation HPRD 18691976
N827 N-Glycosylation PRO 29671580
S862 Phosphorylation HPRD 18691976
S863 Phosphorylation HPRD 18691976
S1011 Phosphorylation HPRD 17322306
S1030 Phosphorylation HPRD 17322306


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q13873-1 (hBMPR2/iso:1) Interaction PR:P12643 (hBMP2) PRO 7791754
PR:Q13873-1 (hBMPR2/iso:1) Interaction PR:P18075 (hBMP7) PRO 7791754


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y247 C247 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ icgc ]
S547 F547 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S586 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y589 C589 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S757 G757 Biomuta DOID:3571 / liver cancer [ cosmic ]
T805 A805 Biomuta DOID:1612 / breast cancer [ cosmic ]
S863 T863 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]