Protein Information

Cytoscape View

UniProt AC / UniProt ID Q13868 / EXOS2_HUMAN
Protein Name Exosome complex component RRP4
Gene Name Name: EXOSC2
Organism Homo sapiens (Human)

PRO ID PR:Q13868
DAG View
PRO Name exosome complex component RRP4 (human)
Definition An exosome complex component RRP4 that is encoded in the genome of human.
Short Label hEXOSC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q13868 (EXOSC2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K24 Ubiquitination PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
R41 Methylation PhosphoSitePlus
T45 Phosphorylation PhosphoSitePlus
Y46 Phosphorylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
C68 S-Nitrosylation dbSNO 19483679
K70 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S124 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 18669648, ...19690332, 20068231
K165 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD 20068231
S124 Phosphorylation HPRD 17322306, 18669648, 19007248, ...20068231, 19691289
S175 Phosphorylation HPRD 19413330
S177 Phosphorylation HPRD 19413330

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T32 A32 Biomuta DOID:363 / uterine cancer [ tcga ]
S124 Y124 Biomuta DOID:363 / uterine cancer [ tcga ]
S175 F175 Biomuta DOID:10534 / stomach cancer [ icgc, tcga ]
K273 N273 Biomuta DOID:3571 / liver cancer [ icgc ]