iPTMnet Report for Q13813 (SPTAN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13813 / SPTN1_HUMAN
Protein Name Spectrin alpha chain, non-erythrocytic 1
Gene Name Name: SPTAN1
Synonyms:NEAS,SPTA2;
Organism Homo sapiens (Human)

PRO ID PR:Q13813
DAG View
PRO Name spectrin alpha chain, non-erythrocytic 1 (human)
Definition A spectrin alpha chain, non-erythrocytic 1 that is encoded in the genome of human.
Short Label hSPTAN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13813 (SPTAN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S33 Phosphorylation PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus
R51 Methylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
R320 Methylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
T330 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
R402 Methylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
Y433 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
R459 Methylation PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
K592 Acetylation PhosphoSitePlus
T595 Phosphorylation PhosphoSitePlus
Y601 Phosphorylation PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
K613 Acetylation PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
K637 Acetylation PhosphoSitePlus   UniProt 19608861
K637 Ubiquitination PhosphoSitePlus
Y644 Phosphorylation PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
K662 Acetylation PhosphoSitePlus
T667 Phosphorylation PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
R733 Methylation PhosphoSitePlus
T738 Phosphorylation PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
Y766 Phosphorylation PhosphoSitePlus
K779 Acetylation PhosphoSitePlus
S783 Phosphorylation PhosphoSitePlus
K803 Ubiquitination PhosphoSitePlus
S809 Phosphorylation PhosphoSitePlus
T810 Phosphorylation PhosphoSitePlus
K814 Ubiquitination PhosphoSitePlus
K824 Ubiquitination PhosphoSitePlus
K825 Ubiquitination PhosphoSitePlus
K864 Ubiquitination PhosphoSitePlus
K871 Acetylation PhosphoSitePlus
K909 Ubiquitination PhosphoSitePlus
K920 Ubiquitination PhosphoSitePlus
S937 Phosphorylation PhosphoSitePlus
Y942 Phosphorylation PhosphoSitePlus
S944 Phosphorylation PhosphoSitePlus
Y976 Phosphorylation PhosphoSitePlus
Y978 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus   UniProt 20068231
K990 Ubiquitination PhosphoSitePlus
T995 Phosphorylation PhosphoSitePlus
S999 Phosphorylation PhosphoSitePlus   UniProt 20068231
T1000 Phosphorylation PhosphoSitePlus
Y1020 Phosphorylation PhosphoSitePlus
K1022 Acetylation PhosphoSitePlus
K1023 Acetylation PhosphoSitePlus
S1029 Phosphorylation PhosphoSitePlus
S1031 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1041 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332, 24275569
T1053 Phosphorylation PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
S1061 Phosphorylation PhosphoSitePlus
S1063 Phosphorylation PhosphoSitePlus
K1067 Ubiquitination PhosphoSitePlus
Y1073 Phosphorylation P12931 (SRC) PhosphoSitePlus 12446661
S1075 Phosphorylation PhosphoSitePlus
K1082 Ubiquitination PhosphoSitePlus
K1093 Acetylation PhosphoSitePlus
T1115 Phosphorylation PhosphoSitePlus
S1116 Phosphorylation PhosphoSitePlus
K1131 Ubiquitination PhosphoSitePlus
K1132 Ubiquitination PhosphoSitePlus
K1138 Methylation PhosphoSitePlus
K1138 Ubiquitination PhosphoSitePlus
S1159 Phosphorylation PhosphoSitePlus
Y1176 Phosphorylation P12931 (SRC) , P06239 (LCK) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19690332, 12446661, 11971983
T1184 Phosphorylation PhosphoSitePlus
S1186 Phosphorylation PhosphoSitePlus
K1187 Ubiquitination PhosphoSitePlus
T1188 Phosphorylation PhosphoSitePlus
S1190 Phosphorylation PhosphoSitePlus
K1193 Ubiquitination PhosphoSitePlus
S1194 Phosphorylation PhosphoSitePlus
T1204 Phosphorylation PhosphoSitePlus
S1207 Phosphorylation PhosphoSitePlus   UniProt 24275569
K1209 Ubiquitination PhosphoSitePlus
S1217 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
S1226 Phosphorylation PhosphoSitePlus
S1231 Phosphorylation PhosphoSitePlus
K1246 Ubiquitination PhosphoSitePlus
K1252 Ubiquitination PhosphoSitePlus
Y1261 Phosphorylation PhosphoSitePlus
K1274 Acetylation PhosphoSitePlus
K1274 Ubiquitination PhosphoSitePlus
K1288 Ubiquitination PhosphoSitePlus
S1291 Phosphorylation PhosphoSitePlus
S1302 Phosphorylation PhosphoSitePlus
S1306 Phosphorylation PhosphoSitePlus   UniProt 24275569
K1313 Ubiquitination PhosphoSitePlus
S1322 Phosphorylation PhosphoSitePlus
S1323 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 24275569
K1326 Ubiquitination PhosphoSitePlus
K1334 Acetylation PhosphoSitePlus
S1338 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1346 Phosphorylation PhosphoSitePlus
S1363 Phosphorylation PhosphoSitePlus
K1369 Acetylation PhosphoSitePlus
T1386 Phosphorylation PhosphoSitePlus
Y1411 Phosphorylation PhosphoSitePlus
S1413 Phosphorylation PhosphoSitePlus
K1419 Ubiquitination PhosphoSitePlus
R1464 Methylation PhosphoSitePlus
K1473 Ubiquitination PhosphoSitePlus
S1476 Phosphorylation PhosphoSitePlus
S1479 Phosphorylation PhosphoSitePlus
K1485 Ubiquitination PhosphoSitePlus
K1486 Acetylation PhosphoSitePlus
K1519 Acetylation PhosphoSitePlus   UniProt 19608861
K1519 Ubiquitination PhosphoSitePlus
R1532 Methylation PhosphoSitePlus
S1545 Phosphorylation PhosphoSitePlus
S1550 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...30379171, 34725712, 26853435, 30620550, 34019948, 35083852, 22121020
S1550 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T1552 Phosphorylation PhosphoSitePlus
S1557 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1578 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y1579 Phosphorylation PhosphoSitePlus
K1580 Ubiquitination PhosphoSitePlus
K1588 Ubiquitination PhosphoSitePlus
K1591 Acetylation PhosphoSitePlus
S1615 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1625 Phosphorylation PhosphoSitePlus
K1630 Ubiquitination PhosphoSitePlus
S1647 Phosphorylation PhosphoSitePlus   UniProt 20068231
K1659 Ubiquitination PhosphoSitePlus
S1692 Phosphorylation PhosphoSitePlus
K1698 Ubiquitination PhosphoSitePlus
K1699 Ubiquitination PhosphoSitePlus
S1708 Phosphorylation PhosphoSitePlus
K1715 Ubiquitination PhosphoSitePlus
S1719 Phosphorylation PhosphoSitePlus
S1751 Phosphorylation PhosphoSitePlus
S1755 Phosphorylation PhosphoSitePlus
K1759 Acetylation PhosphoSitePlus
S1778 Phosphorylation PhosphoSitePlus
K1784 Acetylation PhosphoSitePlus
Y1792 Phosphorylation PhosphoSitePlus
T1797 Phosphorylation PhosphoSitePlus
K1829 Ubiquitination PhosphoSitePlus
K1838 Acetylation PhosphoSitePlus
K1838 Ubiquitination PhosphoSitePlus
K1853 Ubiquitination PhosphoSitePlus
K1856 Ubiquitination PhosphoSitePlus
Y1898 Phosphorylation PhosphoSitePlus
K1911 Acetylation PhosphoSitePlus
K1911 Ubiquitination PhosphoSitePlus
K1923 Ubiquitination PhosphoSitePlus
S1959 Phosphorylation PhosphoSitePlus
K1963 Ubiquitination PhosphoSitePlus
K1995 Ubiquitination PhosphoSitePlus
S2009 Phosphorylation PhosphoSitePlus
S2010 Phosphorylation PhosphoSitePlus
T2016 Phosphorylation PhosphoSitePlus
T2020 Phosphorylation PhosphoSitePlus   UniProt 24275569
K2040 Ubiquitination PhosphoSitePlus
K2047 Acetylation PhosphoSitePlus
K2047 Ubiquitination PhosphoSitePlus
K2052 Acetylation PhosphoSitePlus   UniProt 19608861
K2052 Ubiquitination PhosphoSitePlus
S2066 Phosphorylation PhosphoSitePlus
S2072 Phosphorylation PhosphoSitePlus
K2078 Ubiquitination PhosphoSitePlus
S2084 Phosphorylation PhosphoSitePlus
T2095 Phosphorylation PhosphoSitePlus
K2098 Acetylation PhosphoSitePlus
K2099 Ubiquitination PhosphoSitePlus
R2137 Methylation PhosphoSitePlus
S2138 Phosphorylation PhosphoSitePlus
S2139 Phosphorylation PhosphoSitePlus
S2159 Phosphorylation PhosphoSitePlus
K2187 Ubiquitination PhosphoSitePlus
K2195 Acetylation PhosphoSitePlus
K2205 Acetylation PhosphoSitePlus
K2264 Ubiquitination PhosphoSitePlus
K2281 Ubiquitination PhosphoSitePlus
S2340 Phosphorylation PhosphoSitePlus
K2404 Ubiquitination PhosphoSitePlus
S2411 Phosphorylation PhosphoSitePlus
K2421 Acetylation PhosphoSitePlus   UniProt 19608861
K2421 Ubiquitination PhosphoSitePlus
Y2423 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T2425 Phosphorylation PhosphoSitePlus
K2426 Acetylation PhosphoSitePlus
K2426 Ubiquitination PhosphoSitePlus
Y2430 Phosphorylation PhosphoSitePlus
T2434 Phosphorylation PhosphoSitePlus
Y2440 Phosphorylation PhosphoSitePlus
K2446 Acetylation PhosphoSitePlus
K2452 Ubiquitination PhosphoSitePlus
T2458 Phosphorylation PhosphoSitePlus
Y2462 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T196 Phosphorylation HPRD 18452278
Y644 Phosphorylation HPRD 20068231
T667 Phosphorylation HPRD 20068231
Y766 Phosphorylation HPRD 18491316, 20068231
S783 Phosphorylation HPRD 20068231
S940 Phosphorylation HPRD 20068231
Y978 Phosphorylation HPRD 20068231
S982 Phosphorylation HPRD 20068231
S999 Phosphorylation HPRD 20068231
S1029 Phosphorylation HPRD 20166139, 20068231
S1031 Phosphorylation HPRD 20166139, 19664994
S1041 Phosphorylation HPRD 19664994
Y1073 Phosphorylation HPRD 12446661
S1075 Phosphorylation HPRD 20068231
Y1176 Phosphorylation P12931 (SRC) HPRD 11971983
S1190 Phosphorylation HPRD 20068231
S1217 Phosphorylation HPRD 19664994, 20058876, 19664995, ...18452278, 19651622, 18669648, 20166139, 20068231
S1323 Phosphorylation HPRD 19413330, 15302935, 19664994, ...20068231
Y1411 Phosphorylation HPRD 20068231
S1413 Phosphorylation HPRD 20068231
S1647 Phosphorylation HPRD 20068231
S2138 Phosphorylation HPRD 18452278
S2139 Phosphorylation HPRD 18452278
Y2423 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
S1578 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y1053 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R320 H320 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R320 C320 Biomuta DOID:4159 / skin cancer [ cosmic ]
K335 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R402 G402 Biomuta DOID:3571 / liver cancer [ cosmic ]
R459 C459 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R459 L459 Biomuta DOID:3571 / liver cancer [ cosmic ]
R733 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S809 C809 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y942 H942 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T995 I995 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1022 N1022 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1029 P1029 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1031 F1031 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y1053 C1053 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y1073 C1073 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1207 Y1207 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1231 N1231 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1291 F1291 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1306 * Biomuta DOID:363 / uterine cancer [ cosmic ]
K1334 N1334 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1338 T1338 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R1464 W1464 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1476 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1479 N1479 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K1630 E1630 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1647 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1692 F1692 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1784 Q1784 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S2009 Y2009 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K2040 R2040 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S2066 T2066 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R2137 C2137 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2138 C2138 Biomuta DOID:1612 / breast cancer [ cosmic ]
S2139 P2139 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K2264 N2264 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2411 C2411 Biomuta DOID:3571 / liver cancer [ cosmic ]
T2458 P2458 Biomuta DOID:9256 / colorectal cancer [ cosmic ]