iPTMnet Report for Q13796 (SHROOM2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13796 / SHRM2_HUMAN
Protein Name Protein Shroom2
Gene Name Name: SHROOM2
Synonyms:APXL;
Organism Homo sapiens (Human)

PRO ID PR:Q13796
DAG View
PRO Name protein Shroom2 (human)
Definition A protein Shroom2 that is encoded in the genome of human.
Short Label hSHROOM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13796 (SHROOM2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K55 Ubiquitination PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
K308 Acetylation PhosphoSitePlus
K309 Acetylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
T350 Phosphorylation IEDB 35494241
T366 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S377 Phosphorylation PhosphoSitePlus
S413 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19664995, 24275569
S414 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
T628 Phosphorylation PhosphoSitePlus
S644 Phosphorylation PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
T755 Phosphorylation PhosphoSitePlus
S764 Phosphorylation PhosphoSitePlus
Y778 Phosphorylation PhosphoSitePlus
S779 Phosphorylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus
T846 Phosphorylation PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus   UniProt 24275569
S897 Phosphorylation PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
S921 Phosphorylation PhosphoSitePlus
S922 Phosphorylation PhosphoSitePlus
S974 Phosphorylation PhosphoSitePlus   UniProt 21406692
R1011 Methylation PhosphoSitePlus
T1014 Phosphorylation PhosphoSitePlus
S1022 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation PhosphoSitePlus
T1026 Phosphorylation PhosphoSitePlus
S1036 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 19664995
S1039 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
S1048 Phosphorylation PhosphoSitePlus
Y1075 Phosphorylation PhosphoSitePlus
T1078 Phosphorylation PhosphoSitePlus
S1098 Phosphorylation PhosphoSitePlus
Y1105 Phosphorylation PhosphoSitePlus
S1114 Phosphorylation PhosphoSitePlus
T1163 Phosphorylation PhosphoSitePlus
S1169 Phosphorylation PhosphoSitePlus
S1171 Phosphorylation PhosphoSitePlus
S1173 Phosphorylation PhosphoSitePlus
S1219 Phosphorylation PhosphoSitePlus
S1228 Phosphorylation PhosphoSitePlus
Y1257 Phosphorylation PhosphoSitePlus
S1297 Phosphorylation PhosphoSitePlus
S1337 Phosphorylation PhosphoSitePlus
K1341 Acetylation PhosphoSitePlus
S1373 Phosphorylation PhosphoSitePlus
S1385 Phosphorylation PhosphoSitePlus
S1425 Phosphorylation PhosphoSitePlus
S1427 Phosphorylation PhosphoSitePlus
S1443 Phosphorylation phospho.ELM 17081983
S1504 Phosphorylation PhosphoSitePlus
S1506 Phosphorylation PhosphoSitePlus
S1524 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q14160 (SCRIB) S1508 Q13796 (SHROOM2) unknown eFIP 26101221


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S125 G125 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S204 T204 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S208 L208 Biomuta DOID:4159 / skin cancer [ cosmic ]
S212 P212 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S312 T312 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S312 L312 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T350 M350 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S377 N377 Biomuta DOID:3571 / liver cancer [ cosmic ]
S568 R568 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S644 N644 Biomuta DOID:363 / uterine cancer [ cosmic ]
S646 N646 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T755 I755 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S764 L764 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
S787 F787 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T846 I846 Biomuta DOID:1725 / peritoneum cancer [ cosmic ]
S921 F921 Biomuta DOID:4159 / skin cancer [ cosmic ]
R1011 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1048 L1048 Biomuta DOID:1319 / brain cancer [ icgc ]
T1163 M1163 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S1169 L1169 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S1173 L1173 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1228 R1228 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1425 L1425 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S1504 L1504 Biomuta DOID:363 / uterine cancer [ icgc ]