iPTMnet Report for Q13705 (ACVR2B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13705 / AVR2B_HUMAN
Protein Name Activin receptor type-2B precursor
Gene Name Name: ACVR2B
Organism Homo sapiens (Human)

PRO ID PR:Q13705
DAG View
PRO Name activin receptor type-2B (human)
Definition An activin receptor type-2B that is encoded in the genome of human.
Short Label hACVR2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13705 (ACVR2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
N42 N-Glycosylation GlyGen   UniProt 22718755
N65 N-Glycosylation GlyGen   UniProt 22718755
K224 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
Y387 Phosphorylation IEDB 35494241
T488 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus


Q13705 (ACVR2B) as PTM Enzyme



Substrate Site Score Source PMID
P36896 (ACVR1B) T206 Signor 8622651


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036443 (hACVR2B/iso:ActR-IIB2/NGlycoPhos:1) Interaction PR:Q9UNH7 (hSNX6) PRO 11279102, 9872992


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N65 T65 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K240 * Biomuta DOID:1612 / breast cancer [ cosmic ]