iPTMnet Report for Q13627 (DYRK1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13627 / DYR1A_HUMAN
Protein Name Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Gene Name Name: DYRK1A
Synonyms:DYRK,MNB;
Organism Homo sapiens (Human)

PRO ID PR:Q13627
DAG View
PRO Name dual specificity tyrosine-phosphorylation-regulated kinase 1A (human)
Definition A dual specificity tyrosine-phosphorylation-regulated kinase 1A that is encoded in the genome of human.
Short Label hDYRK1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13627 (DYRK1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Ubiquitination PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus   UniProt 23186163
S22 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus   RLIMS-P 11672423
Y104 Phosphorylation Q13627 (DYRK1A) neXtProt 17229891, 23809146
K105 Acetylation PhosphoSitePlus
Y111 Phosphorylation Q13627 (DYRK1A) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 11672423, 23809146, 23665168, ...17229891
Y112 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
Y140 Phosphorylation Q13627 (DYRK1A) UniProt 23665168
Y145 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 23665168, 18083107, ...15592455, 21878370, 19690332
Y147 Phosphorylation PhosphoSitePlus   RLIMS-P 23665168, 21878370
K150 Ubiquitination PhosphoSitePlus
Y159 Phosphorylation Q13627 (DYRK1A) PhosphoSitePlus   UniProt 23665168
K167 Ubiquitination PhosphoSitePlus
Y177 Phosphorylation Q13627 (DYRK1A) IEDB   UniProt 23665168, 35494241
S258 Phosphorylation RLIMS-P 33380426
K304 Ubiquitination PhosphoSitePlus
S310 Phosphorylation Q13627 (DYRK1A) RLIMS-P   UniProt 23665168, 33380426
Y319 Phosphorylation Q13627 (DYRK1A) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18220336, 23665168, 10910078, ...26234946, 16497976
Y321 Phosphorylation Q13627 (DYRK1A) IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17229891, 18088087, 33393492, ...32357974, 18220336, 11672423, 23665168, 29764512, 29700199, 17192257, 17536841, 10910078, 27796319, 23809146, 15592455, 26234946, 31848261, 27869121, 33380426
S324 Phosphorylation PhosphoSitePlus
S329 Phosphorylation RLIMS-P 24676346
T402 Phosphorylation Q13627 (DYRK1A) UniProt 23665168
Y449 Phosphorylation Q13627 (DYRK1A) UniProt 23665168
K453 Ubiquitination PhosphoSitePlus
T466 Phosphorylation PhosphoSitePlus
S529 Phosphorylation Q13627 (DYRK1A) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17229891, 23809146, 24275569, ...33380426
T532 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
T543 Phosphorylation PhosphoSitePlus
T553 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
Y705 Phosphorylation PhosphoSitePlus
S706 Phosphorylation PhosphoSitePlus
S748 Phosphorylation PhosphoSitePlus   UniProt 18691976
S758 Phosphorylation PhosphoSitePlus   UniProt 18691976
S762 Phosphorylation PhosphoSitePlus
S763 O-Glycosylation GlyGen 32938750
Site PTM Type PTM Enzyme Score Source PMID
Y136 Phosphorylation HPRD 16497976
Y140 Phosphorylation HPRD 16497976
Y145 Phosphorylation HPRD 15592455, 17016520, 16497976
Y147 Phosphorylation HPRD 16497976
Y319 Phosphorylation HPRD 17016520, 16497976
Y321 Phosphorylation HPRD 17016520, 18691976, 17389395, ...18088087, 19413330, 19664994, 19651622, 15592455, 19415658, 20068231, 16497976
S519 Phosphorylation Q13627 (DYRK1A) HPRD 17229891
S529 Phosphorylation HPRD 18691976
S748 Phosphorylation HPRD 18691976
T751 Phosphorylation HPRD 18691976
S758 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation PhosphoSitePlus
Y127 Phosphorylation HPRD 16497976
Y131 Phosphorylation HPRD 16497976
Y136 Phosphorylation HPRD   PhosphoSitePlus 15592455, 17016520, 16497976
Y138 Phosphorylation HPRD 16497976
Y310 Phosphorylation HPRD 17016520, 16497976
Y312 Phosphorylation HPRD 17016520, 18691976, 17389395, ...18088087, 19413330, 19664994, 19651622, 15592455, 19415658, 20068231, 16497976
S520 Phosphorylation Q13627 (DYRK1A) HPRD 17229891, 18691976
S739 Phosphorylation HPRD 18691976
T742 Phosphorylation HPRD 18691976
S749 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
Y136 Phosphorylation HPRD 16497976
Y140 Phosphorylation HPRD 16497976
Y145 Phosphorylation HPRD 15592455, 17016520, 16497976
Y147 Phosphorylation HPRD 16497976
Y319 Phosphorylation HPRD 17016520, 16497976
Y321 Phosphorylation HPRD 17016520, 18691976, 17389395, ...18088087, 19413330, 19664994, 19651622, 15592455, 19415658, 20068231, 16497976
Site PTM Type PTM Enzyme Score Source PMID
Y145 Phosphorylation PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y136 Phosphorylation HPRD 16497976
Y140 Phosphorylation HPRD 16497976
Y145 Phosphorylation HPRD 15592455, 17016520, 16497976
Y147 Phosphorylation HPRD 16497976
Y319 Phosphorylation HPRD 17016520, 16497976
Y321 Phosphorylation HPRD 17016520, 18691976, 17389395, ...18088087, 19413330, 19664994, 19651622, 15592455, 19415658, 20068231, 16497976
S519 Phosphorylation Q13627 (DYRK1A) HPRD 17229891
S529 Phosphorylation HPRD 18691976


Q13627 (DYRK1A) as PTM Enzyme



Substrate Site Score Source PMID
O00401 (WASL) T199 neXtProt 22250195
O00401 (WASL) T205 neXtProt 22250195
O00401 (WASL) T262 neXtProt 22250195
O43524 (FOXO3) S330 Signor 19188143
O43597 (SPRY2) T75 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 20804972, 18678649
O75533 (SF3B1) T273 PhosphoSitePlus 16512921
O75533 (SF3B1) T434 HPRD   neXtProt   PhosphoSitePlus   Signor 23809146, 16512921, 21553260, ...20068231, 19796173
P04637 (TP53) S15 neXtProt   PhosphoSitePlus   Signor 20696760
P10636-8 (MAPT) S199 PhosphoSitePlus 25918155
P10636-8 (MAPT) S202 PhosphoSitePlus 17906291
P10636-8 (MAPT) T205 PhosphoSitePlus 25918155
P10636-8 (MAPT) T212 PhosphoSitePlus 17906291, 25918155, 16987243, ...11311121
P10636-8 (MAPT) T217 PhosphoSitePlus 25918155
P10636 (MAPT) S369 neXtProt 17906291, 21573099, 11311121
P10636-8 (MAPT) S396 PhosphoSitePlus 25918155
P10636-8 (MAPT) S404 PhosphoSitePlus 17906291, 25918155
P10636-8 (MAPT) S422 PhosphoSitePlus 25918155
P10636 (MAPT) S519 neXtProt   Signor 17906291, 21573099, 21215781, ...11311121
P10636 (MAPT) T529 neXtProt   Signor 17906291, 21573099, 21215781, ...11311121
P10636 (MAPT) S721 neXtProt   Signor 17906291, 21573099, 21215781, ...11311121
P24385 (CCND1) T286 PhosphoSitePlus   Signor 24119401
P24928 (POLR2A) S1616 PhosphoSitePlus 25620562
P24928 (POLR2A) S1619 PhosphoSitePlus 25620562
P37840 (SNCA) S87 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 16959772
P46821 (MAP1B) S1400 neXtProt 19549690
P49418 (AMPH) S262 Signor 15262992
P49418 (AMPH) S272 Signor 15262992
P49418 (AMPH) S276 Signor 15262992
P49418 (AMPH) S285 Signor 15262992
P49418 (AMPH) S293 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 16733250
P49418 (AMPH) S295 neXtProt   PhosphoSitePlus   Signor 16733250
P49418 (AMPH) T310 neXtProt   PhosphoSitePlus   Signor 16733250, 15262992
P49418 (AMPH) T312 PhosphoSitePlus 16733250
P49768 (PSEN1) T354 neXtProt 20456003
P53805 (RCAN1) S167 neXtProt   PhosphoSitePlus   Signor 16126726, 12809556, 21965663
P53805 (RCAN1) T247 neXtProt   PhosphoSitePlus 21965663
P55211 (CASP9) T125 neXtProt 19081073, 19016842, 19586613
P61764 (STXBP1) T479 neXtProt 22765017
Q05193 (DNM1) S795 Signor 15287745
Q05193 (DNM1) S857 phospho.ELM   PhosphoSitePlus   Signor 15287745
Q07955 (SRSF1) S227 neXtProt 18658135
Q07955 (SRSF1) S234 neXtProt 18658135
Q07955 (SRSF1) S238 neXtProt   Signor 18658135
Q12778 (FOXO1) S329 HPRD   phospho.ELM   PhosphoSitePlus   Signor 11311120
Q13627 (DYRK1A) Y104 neXtProt 17229891, 23809146
Q13627 (DYRK1A) Y111 neXtProt   UniProt 17229891, 23665168, 23809146
Q13627 (DYRK1A) Y140 UniProt 23665168
Q13627 (DYRK1A) Y159 UniProt 23665168
Q13627 (DYRK1A) Y177 UniProt 23665168
Q13627 (DYRK1A) S310 UniProt 23665168
Q13627 (DYRK1A) Y319 Signor   UniProt 23665168, 10910078
Q13627 (DYRK1A) Y321 neXtProt   Signor   UniProt 11672423, 23665168, 10910078, ...23809146, 17229891
Q13627 (DYRK1A) T402 UniProt 23665168
Q13627 (DYRK1A) Y449 UniProt 23665168
Q13627-1 (DYRK1A) S519 HPRD 17229891
Q13627-2 (DYRK1A) S520 HPRD 17229891, 18691976
Q13627 (DYRK1A) S529 neXtProt   PhosphoSitePlus   Signor 17229891, 23809146
Q49AN0 (CRY2) S558 neXtProt 20123978
Q52LA3 (LIN52) S28 neXtProt   PhosphoSitePlus   Signor 21498570
Q96EB6 (SIRT1) T530 neXtProt 20167603
Q96S94 (CCNL2) S330 PhosphoSitePlus 14623875
Q96S94 (CCNL2) S338 HPRD   PhosphoSitePlus 14623875, 20068231
Q96S94 (CCNL2) S369 HPRD   PhosphoSitePlus 19413330, 19664994, 19664995, ...18452278, 19651622, 18669648, 14623875


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S57 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, cosmic, cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic, cosmic ] DOID:4159 / skin cancer [ cosmic, icgc, cosmic, cosmic, icgc, cosmic ] DOID:5041 / esophageal cancer [ cosmic, cosmic ] DOID:363 / uterine cancer [ cosmic, icgc, cosmic, cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
Y104 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S127 Y127 Biomuta DOID:363 / uterine cancer [ icgc ]
Y127 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y127 C127 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y131 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y136 C136 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y136 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y138 H138 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y138 C138 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y140 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y147 C147 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y147 H147 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S258 C258 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y312 C312 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y321 C321 Biomuta DOID:1324 / lung cancer [ cosmic ]
S324 N324 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S329 T329 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S519 L519 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S706 Y706 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]