iPTMnet Report for Q13625 (TP53BP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13625 / ASPP2_HUMAN
Protein Name Apoptosis-stimulating of p53 protein 2
Gene Name Name: TP53BP2
Synonyms:ASPP2,BBP;
Organism Homo sapiens (Human)

PRO ID PR:Q13625
DAG View
PRO Name apoptosis-stimulating of p53 protein 2 (human)
Definition An apoptosis-stimulating of p53 protein 2 that is encoded in the genome of human.
Short Label hTP53BP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13625 (TP53BP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
S136 O-Glycosylation GlyGen 35132862, 30379171, 30059200, ...35254053, 34019948, 31492838, 30620550
K152 Ubiquitination PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
R265 Methylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
S328 O-Glycosylation GlyGen 35132862, 30379171, 30059200, ...35254053, 34019948, 31492838, 30620550
S329 O-Glycosylation GlyGen 35132862, 30379171, 30059200, ...35254053, 34019948, 31492838, 30620550
S339 O-Glycosylation GlyGen 34019948, 30379171, 32938750, ...30059200, 35254053, 35132862, 31492838, 30620550
S342 O-Glycosylation GlyGen 35132862, 30379171, 30059200, ...35254053, 34019948, 31492838, 30620550
Y350 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus
S414 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S458 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
T474 Phosphorylation PhosphoSitePlus
S480 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
S481 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
S556 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S558 Phosphorylation PhosphoSitePlus
S569 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S572 Phosphorylation PhosphoSitePlus   UniProt 20068231
S576 Phosphorylation PhosphoSitePlus   UniProt 23186163
T586 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 22028470
T603 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
S608 O-Glycosylation GlyGen 35132862, 30379171, 30059200, ...35254053, 34019948, 31492838, 30620550
Y610 Phosphorylation PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus
Y613 Phosphorylation PhosphoSitePlus
Y645 Phosphorylation PhosphoSitePlus
Y664 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
S698 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
T700 Phosphorylation PhosphoSitePlus
Y710 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus   UniProt 23186163
K724 Ubiquitination PhosphoSitePlus
S736 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S737 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T739 Phosphorylation PhosphoSitePlus
S783 Phosphorylation PhosphoSitePlus
Y791 Phosphorylation PhosphoSitePlus
S827 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   RLIMS-P 24312625
Y869 Phosphorylation PhosphoSitePlus
Y874 Phosphorylation PhosphoSitePlus
Y947 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S291 Phosphorylation HPRD 18669648
S357 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664994, 20068231
S433 Phosphorylation HPRD 19413330, 18669648, 15144186, ...20068231
S435 Phosphorylation HPRD 20068231
S446 Phosphorylation HPRD 18669648, 15144186, 20068231
S449 Phosphorylation HPRD 20068231
S550 Phosphorylation HPRD 20068231
S575 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231
T577 Phosphorylation HPRD 17322306, 19651622, 20166139, ...20068231
S613 Phosphorylation HPRD 18669648
S614 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S420 Phosphorylation HPRD 18669648
S486 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664994, 20068231
S562 Phosphorylation HPRD 19413330, 18669648, 15144186, ...20068231
S564 Phosphorylation HPRD 20068231
S575 Phosphorylation HPRD 18669648, 15144186, 20068231
S578 Phosphorylation HPRD 20068231
S679 Phosphorylation HPRD 20068231
S704 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231
T706 Phosphorylation HPRD 17322306, 19651622, 20166139, ...20068231
S742 Phosphorylation HPRD 18669648
S743 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S357 G357 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S486 G486 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S614 C614 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
S614 Y614 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S743 C743 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
S743 Y743 Biomuta DOID:9256 / colorectal cancer [ cosmic ]