iPTMnet Report for Q13619 (CUL4A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13619 / CUL4A_HUMAN
Protein Name Cullin-4A
Gene Name Name: CUL4A
Organism Homo sapiens (Human)

PRO ID PR:Q13619
DAG View
PRO Name cullin-4A (human)
Definition A cullin-4A that is encoded in the genome of human.
Short Label hCUL4A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13619 (CUL4A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
S10 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
S12 Phosphorylation PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
K23 Acetylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
K41 Acetylation PhosphoSitePlus
K42 Acetylation PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
C143 Methylation IEDB 31844290
S151 Phosphorylation PhosphoSitePlus
Y227 Phosphorylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
C241 Methylation IEDB 31844290
Y259 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
T276 O-Glycosylation GlyGen 29351928, 34725712, 28510447
K284 Ubiquitination PhosphoSitePlus
R330 Methylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
K422 Acetylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
T425 Phosphorylation PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
K555 Acetylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
C633 Methylation IEDB 31844290
C633 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
K635 Ubiquitination PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
R692 Methylation PhosphoSitePlus
R702 Methylation PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
K724 Ubiquitination PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
K733 Ubiquitination PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
R742 Methylation PhosphoSitePlus
Y744 Phosphorylation PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 18691976, 18212344, 19651622, ...18669648, 20166139, 20068231
S99 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C143 R143 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y227 C227 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y259 H259 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y259 * Biomuta DOID:1612 / breast cancer [ cosmic ]
R330 S330 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K369 Q369 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K391 R391 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K555 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K646 N646 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K705 N705 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K708 N708 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S738 F738 Biomuta DOID:9256 / colorectal cancer [ cosmic ]