Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13618 / CUL3_HUMAN
Protein Name Cullin-3
Gene Name Name: CUL3
Synonyms:KIAA0617;
Organism Homo sapiens (Human)

PRO ID PR:Q13618
DAG View
PRO Name cullin-3 (human)
Definition A cullin-3 that is encoded in the genome of human.
Short Label hCUL3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13618 (CUL3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
K6 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
Y58 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
T63 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
T312 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
Y320 Phosphorylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
R364 Methylation PhosphoSitePlus
Y387 Phosphorylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
T442 Phosphorylation PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
K459 Acetylation PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
T483 Phosphorylation PhosphoSitePlus
Y512 Phosphorylation PhosphoSitePlus
T519 Phosphorylation PhosphoSitePlus
R536 Methylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus   UniProt 23186163
K638 Ubiquitination PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
K651 Acetylation PhosphoSitePlus
K651 Ubiquitination PhosphoSitePlus
K668 Ubiquitination PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
S684 Phosphorylation PhosphoSitePlus
K700 Ubiquitination PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
S737 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
Y764 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S737 Phosphorylation HPRD 15302935, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O94844 (RHOBTB1) T398 Q13618 (CUL3) increased_association eFIP 31431478
Phosphorylation Q9Y6Q9 (NCOA3) S860 Q13618 (CUL3) increased_association eFIP 22147914


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 * Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K6 E6 Biomuta DOID:1324 / lung cancer [ cosmic ]
S50 N50 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K326 Q326 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K349 N349 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R364 C364 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T442 R442 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T483 M483 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]