iPTMnet Report for Q13617 (CUL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13617 / CUL2_HUMAN
Protein Name Cullin-2
Gene Name Name: CUL2
Organism Homo sapiens (Human)

PRO ID PR:Q13617
DAG View
PRO Name cullin-2 (human)
Definition A cullin-2 that is encoded in the genome of human.
Short Label hCUL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13617 (CUL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K16 Ubiquitination PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
Y43 Phosphorylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
Y298 Phosphorylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K393 Acetylation PhosphoSitePlus   UniProt 19608861
K393 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
R414 Methylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
Y477 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
T661 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K689 Ubiquitination PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T661 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y43 C43 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K238 N238 Biomuta DOID:1612 / breast cancer [ icgc ]
S481 N481 Biomuta DOID:1324 / lung cancer [ cosmic ]
S616 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S637 L637 Biomuta DOID:9256 / colorectal cancer [ cosmic ]