Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13616 / CUL1_HUMAN
Protein Name Cullin-1
Gene Name Name: CUL1
Organism Homo sapiens (Human)

PRO ID PR:Q13616
DAG View
PRO Name cullin-1 (human)
Definition A fungal/metazoan cullin-1 that is encoded in the genome of human.
Short Label hCUL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13616 (CUL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
K13 Acetylation PhosphoSitePlus
R63 Methylation PhosphoSitePlus   UniProt 24129315
S70 Phosphorylation HPRD   PhosphoSitePlus 20068231
K73 Methylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus
T101 Phosphorylation HPRD 20068231
K131 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
T409 Phosphorylation PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
Y425 Phosphorylation PhosphoSitePlus
K431 Acetylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
K689 Acetylation PhosphoSitePlus
K689 Ubiquitination PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
K751 Ubiquitination PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q6R327 (RICTOR) T1135 Q13616 (CUL1) inhibited_association eFIP 21204013
Phosphorylation Q6R327 (RICTOR) T1135 Q13616 (CUL1) inhibited_association eFIP 20832730


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P62877-1 (hRBX1/iso:1) Interaction PR:Q13616-1 (hCUL1/iso:1) PRO 11961546
PR:P63208-1 (hSKP1/iso:1) Interaction PR:Q13616-1 (hCUL1/iso:1) PRO 12609982
PR:Q13616-1 (hCUL1/iso:1) Interaction PR:Q86VP6-1 (hCAND1/iso:1) PRO 12504026, 15537541
PR:Q13616-1 (hCUL1/iso:1) Interaction PR:P62877-1 (hRBX1/iso:1) PRO 12504026, 15537541


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 I6 Biomuta DOID:1324 / lung cancer [ cosmic ]
K13 Q13 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K73 E73 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K74 R74 Biomuta DOID:3571 / liver cancer [ tcga ]
K74 N74 Biomuta DOID:11934 / head and neck cancer [ icgc ]
K464 T464 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K493 M493 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]