iPTMnet Report for Q13616 (CUL1)
Protein Information
| UniProt AC / UniProt ID | Q13616 / CUL1_HUMAN |
| Protein Name | Cullin-1 |
| Gene Name | Name: CUL1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q13616 |
| PRO Name | cullin-1 (human) |
| Definition | A fungal/metazoan cullin-1 that is encoded in the genome of human. |
| Short Label | hCUL1 |
| Category | organism-gene |
DAG ViewQ13616 (CUL1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S6 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K13 | Acetylation | score1 | PhosphoSitePlus | |||
| R63 | Methylation | score2 | PhosphoSitePlus UniProt | 24129315 | ||
| S70 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
| K73 | Methylation | score1 | PhosphoSitePlus | |||
| K74 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T77 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T101 | Phosphorylation | score0 | HPRD | 20068231 | ||
| K131 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K290 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C355 | Methylation | score1 | IEDB | 31844290 | ||
| T409 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K410 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K417 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y425 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K431 | Acetylation | score1 | PhosphoSitePlus | |||
| K464 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K468 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K493 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K522 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K587 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K689 | Acetylation | score1 | PhosphoSitePlus | |||
| K689 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K708 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K720 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K751 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K769 | Ubiquitination | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q6R327 (RICTOR) | T1135 | Q13616 (CUL1) | inhibited_association | eFIP | 21204013 | |
| Phosphorylation | Q6R327 (RICTOR) | T1135 | Q13616 (CUL1) | inhibited_association | eFIP | 20832730 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:P62877-1 (hRBX1/iso:1) | Interaction | PR:Q13616-1 (hCUL1/iso:1) | PRO | 11961546 | |
| PR:P63208-1 (hSKP1/iso:1) | Interaction | PR:Q13616-1 (hCUL1/iso:1) | PRO | 12609982 | |
| PR:Q13616-1 (hCUL1/iso:1) | Interaction | PR:Q86VP6-1 (hCAND1/iso:1) | PRO | 12504026, 15537541 | |
| PR:Q13616-1 (hCUL1/iso:1) | Interaction | PR:P62877-1 (hRBX1/iso:1) | PRO | 12504026, 15537541 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S6 | I6 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| K13 | Q13 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| R63 | Q63 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K73 | E73 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K74 | N74 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| K464 | T464 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| K493 | Q493 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K493 | M493 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] |
