iPTMnet Report for Q13595 (TRA2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13595 / TRA2A_HUMAN
Protein Name Transformer-2 protein homolog alpha
Gene Name Name: TRA2A
Organism Homo sapiens (Human)

PRO ID PR:Q13595
DAG View
PRO Name transformer-2 protein homolog alpha (human)
Definition A transformer-2 protein homolog alpha that is encoded in the genome of human.
Short Label hTRA2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13595 (TRA2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 19369195, 21406692, ...22814378, 20068231
S2 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...17081983, 16097034, 20068231
S14 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...20068231
S16 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S18 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S20 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T22 Phosphorylation PhosphoSitePlus
T24 Phosphorylation PhosphoSitePlus   UniProt 21406692
S30 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
S64 Phosphorylation phospho.ELM 17081983
S71 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S82 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S84 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...17081983
S86 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 23186163, ...17081983
Y87 Phosphorylation PhosphoSitePlus
T88 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...17081983
Y91 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus   UniProt 21406692
S98 Phosphorylation PhosphoSitePlus   UniProt 21406692
S100 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
R160 Methylation PhosphoSitePlus
Y166 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
R188 Methylation PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
T202 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...20068231, 27869121
T204 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...20068231, 27869121
Y208 Phosphorylation PhosphoSitePlus
S215 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S236 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y237 Phosphorylation PhosphoSitePlus
R240 Methylation PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
Y249 Phosphorylation PhosphoSitePlus
Y252 Phosphorylation PhosphoSitePlus
Y254 Phosphorylation PhosphoSitePlus
Y256 Phosphorylation PhosphoSitePlus
S260 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17287340, 16964243, ...17081983
S262 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340, 17081983, 18220336, ...18669648, 16964243
Y264 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107, 18669648
Y265 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S266 Phosphorylation PhosphoSitePlus
Y268 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 19007248
S14 Phosphorylation HPRD 19651622, 17081983, 20068231
S16 Phosphorylation HPRD 19651622, 17081983
S18 Phosphorylation HPRD 17081983
S20 Phosphorylation HPRD 19651622, 20068231
T22 Phosphorylation HPRD 19651622, 17081983
T24 Phosphorylation HPRD 19651622, 17081983
S30 Phosphorylation HPRD 19651622
S32 Phosphorylation HPRD 19651622
S34 Phosphorylation HPRD 19651622
S38 Phosphorylation HPRD 19651622
S40 Phosphorylation HPRD 19651622
S43 Phosphorylation HPRD 19651622
S50 Phosphorylation HPRD 17081983
S71 Phosphorylation HPRD 19651622
S73 Phosphorylation HPRD 19651622
S75 Phosphorylation HPRD 19651622
S77 Phosphorylation HPRD 19651622
S82 Phosphorylation HPRD 19651622, 17081983
S84 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S86 Phosphorylation HPRD 19651622, 20166139, 18669648, ...17081983, 20068231
Y87 Phosphorylation HPRD 19651622, 17081983
T88 Phosphorylation HPRD 17322306, 18767875, 19664994, ...19651622, 18669648, 20166139, 20068231, 20068230
Y91 Phosphorylation HPRD 17081983
S96 Phosphorylation HPRD 19651622, 17081983, 20068231
S98 Phosphorylation HPRD 19651622, 17081983, 20068231
S100 Phosphorylation HPRD 19651622, 17081983, 20068231
S103 Phosphorylation HPRD 19651622
T109 Phosphorylation HPRD 20068231
Y194 Phosphorylation HPRD 20068231
S195 Phosphorylation HPRD 20068231
T197 Phosphorylation HPRD 20068231
T202 Phosphorylation HPRD 19413330, 17081983, 18452278, ...19651622, 18669648, 20068231
T204 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
Y208 Phosphorylation HPRD 17081983
T213 Phosphorylation HPRD 17081983
S215 Phosphorylation HPRD 18669648, 17081983, 20068231
S236 Phosphorylation HPRD 17322306, 18212344
S260 Phosphorylation HPRD 19413330, 18212344, 16964243, ...18767875, 19664995, 19651622, 18669648, 18707149, 20166139, 20068231, 17924679
S262 Phosphorylation HPRD 19413330, 18212344, 16964243, ...18767875, 19664995, 19651622, 18669648, 20166139, 20068231, 17924679
Y264 Phosphorylation HPRD 18767875, 18669648, 20068231
Y265 Phosphorylation HPRD 20068231
S266 Phosphorylation HPRD 19651622, 20068231
Y268 Phosphorylation HPRD 20068231
S272 Phosphorylation HPRD 19651622
S274 Phosphorylation HPRD 19651622
S276 Phosphorylation HPRD 19651622
Y277 Phosphorylation HPRD 19651622
S278 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 R2 Biomuta DOID:263 / kidney cancer [ cosmic ]
S14 F14 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S16 C16 Biomuta DOID:3571 / liver cancer [ cosmic ]
S20 Y20 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T22 M22 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S30 L30 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S34 L34 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S36 F36 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S77 C77 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S86 L86 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S96 N96 Biomuta DOID:1324 / lung cancer [ cosmic ]
T109 S109 Biomuta DOID:1324 / lung cancer [ cosmic ]
T109 A109 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T109 N109 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R160 G160 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R160 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R188 G188 Biomuta DOID:3571 / liver cancer [ cosmic ]
R188 T188 Biomuta DOID:4159 / skin cancer [ cosmic ]
R188 S188 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S195 C195 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K198 E198 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y237 H237 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R240 I240 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y249 * Biomuta DOID:184 / bone cancer [ cosmic ]
Y252 C252 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S262 P262 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S274 C274 Biomuta DOID:4159 / skin cancer [ cosmic ]