iPTMnet Report for Q13564 (NAE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13564 / ULA1_HUMAN
Protein Name NEDD8-activating enzyme E1 regulatory subunit
Gene Name Name: NAE1
Synonyms:APPBP1;ORFNames:HPP1;
Organism Homo sapiens (Human)

PRO ID PR:Q13564
DAG View
PRO Name NEDD8-activating enzyme E1 regulatory subunit (human)
Definition A NEDD8-activating enzyme E1 regulatory subunit that is encoded in the genome of human.
Short Label hNAE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13564 (NAE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K6 Acetylation PhosphoSitePlus   UniProt 19608861
K6 Ubiquitination PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
Y13 Phosphorylation PhosphoSitePlus
C34 Methylation IEDB 31844290
T124 Phosphorylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
Y226 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K253 Sumoylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
K338 Acetylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
Y339 Phosphorylation PhosphoSitePlus
K341 Acetylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
Y346 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
K378 Acetylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
Y448 Phosphorylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K7 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K187 R187 Biomuta DOID:1324 / lung cancer [ cosmic ]
K206 R206 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K207 E207 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K238 E238 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K317 N317 Biomuta DOID:4159 / skin cancer [ cosmic ]
S376 L376 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y448 C448 Biomuta DOID:4159 / skin cancer [ cosmic ]