iPTMnet Report for Q13563 (PKD2)
Protein Information
UniProt AC / UniProt ID | Q13563 / PKD2_HUMAN |
Protein Name | Polycystin-2 |
Gene Name | Name: PKD2 Synonyms:TRPP2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q13563 |
PRO Name | polycystin-2 (human) |
Definition | A polycystin-2 that is encoded in the genome of human. |
Short Label | hPKD2 |
Category | organism-gene |
Q13563 (PKD2) as Substrate
Site | PTM Type | PTM Enzyme |
Score
| Source | PMID | |
---|---|---|---|---|---|---|
S74 | Phosphorylation | score1 | PhosphoSitePlus | |||
S76 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P Signor UniProt | 16551655 | ||
S76 | Phosphorylation | P49840 (GSK3A) | score3 | PhosphoSitePlus Signor | 16551655 | |
S80 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 16551655 | ||
S125 | Phosphorylation | score1 | PhosphoSitePlus | |||
S133 | Phosphorylation | score1 | PhosphoSitePlus | |||
S138 | Phosphorylation | score1 | PhosphoSitePlus | |||
R139 | Methylation | score1 | PhosphoSitePlus | |||
S151 | Phosphorylation | score1 | PhosphoSitePlus | |||
S166 | Phosphorylation | score1 | PhosphoSitePlus | |||
S244 | Phosphorylation | score0 | RLIMS-P | 17962809 | ||
S254 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17287340 | ||
T260 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17287340 | ||
S263 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17287340 | ||
N299 | N-Glycosylation | score4 | GlyGen UniProt | 28092368, 24190977 | ||
N305 | N-Glycosylation | score4 | GlyGen UniProt | 28092368, 24190977 | ||
S307 | Phosphorylation | score1 | PhosphoSitePlus | |||
N328 | N-Glycosylation | score4 | GlyGen UniProt | 27768895, 27991905, 19139490, ...28092368 | ||
S330 | O-Glycosylation | score1 | GlyGen | 35289036 | ||
N362 | N-Glycosylation | score4 | GlyGen UniProt | 27768895, 27991905, 28092368 | ||
T364 | O-Glycosylation | score1 | GlyGen | 35289036 | ||
N375 | N-Glycosylation | score4 | GlyGen UniProt | 27768895, 27991905, 28092368 | ||
S408 | Phosphorylation | score1 | PhosphoSitePlus | |||
T588 | Phosphorylation | score1 | PhosphoSitePlus | |||
S591 | Phosphorylation | score1 | PhosphoSitePlus | |||
K695 | Ubiquitination | score1 | PhosphoSitePlus | |||
K719 | Ubiquitination | score1 | PhosphoSitePlus | |||
K735 | Ubiquitination | score1 | PhosphoSitePlus | |||
T751 | Phosphorylation | score1 | PhosphoSitePlus | |||
S801 | Phosphorylation | score4 | PhosphoSitePlus Signor UniProt | 16551655, 20881056 | ||
S801 | Phosphorylation | Q15139 (PRKD1) | score1 | Signor | 20881056 | |
S801 | Phosphorylation | Q9BZL6 (PRKD2) | score2 | PhosphoSitePlus | 20881056 | |
S808 | Phosphorylation | score1 | PhosphoSitePlus | |||
S812 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 21406692, 21670214, 14742446, ...24275569, 16551655, 15692563 | ||
S812 | Phosphorylation | P68400 (CSNK2A1) | score3 | PhosphoSitePlus Signor | 14742446 | |
S829 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P UniProt | 26269590, 21670214, 23390129 | ||
S829 | Phosphorylation | O14965 (AURKA) | score2 | neXtProt | 21670214 | |
S829 | Phosphorylation | P17612 (PRKACA) | score3 | PhosphoSitePlus | 26269590, 23390129 | |
S852 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17287340 | ||
S858 | Phosphorylation | score1 | phospho.ELM | 17287340 | ||
S944 | Phosphorylation | score0 | RLIMS-P | 21670214 | ||
S949 | Phosphorylation | score1 | PhosphoSitePlus | |||
T952 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme |
Score
| Source | PMID | |
---|---|---|---|---|---|---|
S166 | Phosphorylation | score0 | HPRD | 17081983 | ||
S254 | Phosphorylation | score0 | HPRD | 17287340 | ||
T260 | Phosphorylation | score0 | HPRD | 17287340 | ||
S263 | Phosphorylation | score0 | HPRD | 17287340 | ||
S812 | Phosphorylation | score0 | HPRD | 19651622 | ||
S852 | Phosphorylation | score0 | HPRD | 17287340 | ||
S949 | Phosphorylation | score0 | HPRD | 18077418 |
Q13563 (PKD2) as PTM Enzyme
Substrate | Site | Score | Source | PMID | |
---|---|---|---|---|---|
Q9BZL6 (PRKD2) | S876 | score3 | phospho.ELM | 11062248, 12058027 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S254 | * | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
S263 | F263 | Biomuta | [ cosmic ] DOID:1115 / sarcoma [ icgc ] | |
T364 | A364 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S408 | I408 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
T751 | A751 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
T751 | I751 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S812 | F812 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S829 | C829 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S858 | P858 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S858 | T858 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S949 | F949 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
T952 | A952 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] |
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