iPTMnet Report Q13563 PKD2

Protein Information

UniProt AC / UniProt ID	Q13563 / PKD2_HUMAN
Protein Name	Polycystin-2
Gene Name	Name: PKD2 Synonyms:TRPP2;
Organism	Homo sapiens (Human)

PRO ID	PR:Q13563 DAG View
PRO Name	polycystin-2 (human)
Definition	A polycystin-2 that is encoded in the genome of human.
Short Label	hPKD2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q13563 (PKD2) as Substrate

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine By position S74 S76 S80 S125 S133 S138 R139 S151 S166 S244 S254 T260 S263 N299 N305 S307 N328 S330 N362 T364 N375 S408 T588 S591 K695 K719 K735 T751 S801 S808 S812 S829 S852 S858 S944 S949 T952	PTM Type Select all Methylation N-Glycosylation O-Glycosylation Phosphorylation Ubiquitination	PTM Enzyme Select all O14965 (AURKA) P17612 (PRKACA) P49840 (GSK3A) P68400 (CSNK2A1) Q15139 (PRKD1) Q9BZL6 (PRKD2)	Score Select all 0 1 2 3 4	Source Select all GlyGen PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
S74	Phosphorylation		score1	PhosphoSitePlus
S76	Phosphorylation		score3	PhosphoSitePlus RLIMS-P Signor UniProt	16551655
S76	Phosphorylation	P49840 (GSK3A)	score3	PhosphoSitePlus Signor	16551655
S80	Phosphorylation		score3	PhosphoSitePlus UniProt	16551655
S125	Phosphorylation		score1	PhosphoSitePlus
S133	Phosphorylation		score1	PhosphoSitePlus
S138	Phosphorylation		score1	PhosphoSitePlus
R139	Methylation		score1	PhosphoSitePlus
S151	Phosphorylation		score1	PhosphoSitePlus
S166	Phosphorylation		score1	PhosphoSitePlus
S244	Phosphorylation		score0	RLIMS-P	17962809
S254	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17287340
T260	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17287340
S263	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17287340
N299	N-Glycosylation		score4	GlyGen UniProt	28092368, 24190977
N305	N-Glycosylation		score4	GlyGen UniProt	28092368, 24190977
S307	Phosphorylation		score1	PhosphoSitePlus
N328	N-Glycosylation		score4	GlyGen UniProt	27768895, 27991905, 19139490, ...28092368
S330	O-Glycosylation		score1	GlyGen	35289036
N362	N-Glycosylation		score4	GlyGen UniProt	27768895, 27991905, 28092368
T364	O-Glycosylation		score1	GlyGen	35289036
N375	N-Glycosylation		score4	GlyGen UniProt	27768895, 27991905, 28092368
S408	Phosphorylation		score1	PhosphoSitePlus
T588	Phosphorylation		score1	PhosphoSitePlus
S591	Phosphorylation		score1	PhosphoSitePlus
K695	Ubiquitination		score1	PhosphoSitePlus
K719	Ubiquitination		score1	PhosphoSitePlus
K735	Ubiquitination		score1	PhosphoSitePlus
T751	Phosphorylation		score1	PhosphoSitePlus
S801	Phosphorylation		score4	PhosphoSitePlus Signor UniProt	16551655, 20881056
S801	Phosphorylation	Q15139 (PRKD1)	score1	Signor	20881056
S801	Phosphorylation	Q9BZL6 (PRKD2)	score2	PhosphoSitePlus	20881056
S808	Phosphorylation		score1	PhosphoSitePlus
S812	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	21406692, 21670214, 14742446, ...24275569, 16551655, 15692563
S812	Phosphorylation	P68400 (CSNK2A1)	score3	PhosphoSitePlus Signor	14742446
S829	Phosphorylation		score4	neXtProt PhosphoSitePlus RLIMS-P UniProt	26269590, 21670214, 23390129
S829	Phosphorylation	O14965 (AURKA)	score2	neXtProt	21670214
S829	Phosphorylation	P17612 (PRKACA)	score3	PhosphoSitePlus	26269590, 23390129
S852	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17287340
S858	Phosphorylation		score1	phospho.ELM	17287340
S944	Phosphorylation		score0	RLIMS-P	21670214
S949	Phosphorylation		score1	PhosphoSitePlus
T952	Phosphorylation		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Threonine By position S166 S254 T260 S263 S812 S852 S949	PTM Type Select all Phosphorylation	Score Select all 0	Source Select all HPRD	PMID
S166	Phosphorylation	score0	HPRD	17081983
S254	Phosphorylation	score0	HPRD	17287340
T260	Phosphorylation	score0	HPRD	17287340
S263	Phosphorylation	score0	HPRD	17287340
S812	Phosphorylation	score0	HPRD	19651622
S852	Phosphorylation	score0	HPRD	17287340
S949	Phosphorylation	score0	HPRD	18077418

Q13563 (PKD2) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

	Substrate Select all Q9BZL6 (PRKD2)	Site Select all By amino acid All Serine By position S876	Score Select all 3	Source Select all phospho.ELM	PMID
	Q9BZL6 (PRKD2)	S876	score3	phospho.ELM	11062248, 12058027

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position S254 S263 T364 S408 T751 S812 S829 S858 S949 T952	Variant Select all * A364 A751 A952 C829 F263 F812 F949 I408 I751 P858 T858	Source Select all Biomuta	Disease [Sample source] Select all DOID:1324 / lung cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S254	*	Biomuta	DOID:363 / uterine cancer [ cosmic ]
S263	F263	Biomuta	[ cosmic ] DOID:1115 / sarcoma [ icgc ]
T364	A364	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S408	I408	Biomuta	DOID:5041 / esophageal cancer [ cosmic, icgc ]
T751	A751	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
T751	I751	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S812	F812	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S829	C829	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S858	P858	Biomuta	DOID:363 / uterine cancer [ icgc ]
S858	T858	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S949	F949	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T952	A952	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q13563 (PKD2)

Protein Information

Interactive Sequence View

Q13563 (PKD2) as Substrate

Q13563 (PKD2) as PTM Enzyme

PTM sites affected in variants