Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13557 / KCC2D_HUMAN
Protein Name Calcium/calmodulin-dependent protein kinase type II subunit delta
Gene Name Name: CAMK2D
Synonyms:CAMKD;
Organism Homo sapiens (Human)

PRO ID PR:Q13557
DAG View
PRO Name calcium/calmodulin-dependent protein kinase type II subunit delta (human)
Definition A calcium/calmodulin-dependent protein kinase type II subunit delta that is encoded in the genome of human.
Short Label hCAMK2D
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13557 (CAMK2D) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19369195
S3 Phosphorylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K57 Acetylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
K227 Acetylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
Y231 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
T287 Phosphorylation Q13557 (CAMK2D) neXtProt   PRO   PhosphoSitePlus   UniProt 19671701, 16690701
K299 Methylation PhosphoSitePlus
K301 Methylation PhosphoSitePlus
T306 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
S315 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 24275569, 17192257
K318 Acetylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
S319 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 24275569, 17192257
S330 Phosphorylation PhosphoSitePlus   UniProt 24275569
T331 Phosphorylation PhosphoSitePlus   UniProt 24275569
S333 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
T337 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24275569, 17192257
C373 S-Nitrosylation dbSNO 21278135
S404 Phosphorylation PhosphoSitePlus   UniProt 19369195
S441 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
T474 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus   UniProt 19369195
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 18691976
T287 Phosphorylation HPRD 10852918
S315 Phosphorylation Q13557 (CAMK2D) HPRD 20166139, 18691976, 17192257, ...20068231
S319 Phosphorylation Q13557 (CAMK2D) HPRD 18691976, 17192257, 20068231
S330 Phosphorylation HPRD 20166139, 18691976
T331 Phosphorylation Q13557 (CAMK2D) HPRD 20166139, 18691976, 17192257
S333 Phosphorylation Q13557 (CAMK2D) HPRD 19413330, 18691976, 17192257
S334 Phosphorylation Q13557 (CAMK2D) HPRD 18691976, 17192257
T336 Phosphorylation HPRD 18691976, 18452278
T337 Phosphorylation Q13557 (CAMK2D) HPRD 20166139, 18691976, 17192257, ...18452278
S472 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 18691976
T287 Phosphorylation HPRD 10852918
S315 Phosphorylation Q13557 (CAMK2D) HPRD 20166139, 18691976, 17192257, ...20068231
S319 Phosphorylation Q13557 (CAMK2D) HPRD 18691976, 17192257, 20068231
S330 Phosphorylation HPRD 20166139, 18691976
T331 Phosphorylation Q13557 (CAMK2D) HPRD 20166139, 18691976, 17192257
S333 Phosphorylation Q13557 (CAMK2D) HPRD 19413330, 18691976, 17192257
S334 Phosphorylation Q13557 (CAMK2D) HPRD 18691976, 17192257
T336 Phosphorylation HPRD 18691976, 18452278
T337 Phosphorylation Q13557 (CAMK2D) HPRD 20166139, 18691976, 17192257, ...18452278
Site PTM Type PTM Enzyme Score Source PMID
T287 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 18691976
T287 Phosphorylation HPRD   PhosphoSitePlus 10852918
S315 Phosphorylation Q13557 (CAMK2D) HPRD 20166139, 18691976, 17192257, ...20068231
S319 Phosphorylation Q13557 (CAMK2D) HPRD 18691976, 17192257, 20068231
S330 Phosphorylation HPRD 20166139, 18691976
T331 Phosphorylation Q13557 (CAMK2D) HPRD 20166139, 18691976, 17192257
S333 Phosphorylation Q13557 (CAMK2D) HPRD 19413330, 18691976, 17192257
S334 Phosphorylation Q13557 (CAMK2D) HPRD 18691976, 17192257
T336 Phosphorylation HPRD 18691976, 18452278
T337 Phosphorylation Q13557 (CAMK2D) HPRD 20166139, 18691976, 17192257, ...18452278
S472 Phosphorylation HPRD 18691976


Q13557 (CAMK2D) as PTM Enzyme



Substrate Site Score Source PMID
O15084 (ANKRD28) S1011 PhosphoSitePlus 17023142
P08670 (VIM) S83 HPRD 20166139, 18669648, 15345747, ...10852918, 20068231
P13688-8 (CEACAM1) T457 PhosphoSitePlus   Signor 24302721
P13688-8 (CEACAM1) S459 PhosphoSitePlus 24302721
P16220 (CREB1) S142 neXtProt 22554507
P26678 (PLN) T17 neXtProt 19671701, 19608982, 21998325, ...17234969
P55327 (TPD52) S176 neXtProt   PhosphoSitePlus   Signor 20946871, 20032513, 18832449
P56524 (HDAC4) S210 neXtProt   PhosphoSitePlus   Signor 17179159, 22360269
P56524 (HDAC4) S632 neXtProt 17179159, 22360269
Q00613 (HSF1) S230 neXtProt 19910575
Q03060-16 (CREM) S87 HPRD 8404858
Q08289-2 (CACNB2) T499 PhosphoSitePlus 20194790
Q08289 (CACNB2) T554 Signor 20194790
Q13557 (CAMK2D) T287 neXtProt   UniProt 19671701, 16690701
Q13557-12 (CAMK2D) S315 HPRD 20166139, 18691976, 17192257, ...20068231
Q13557-1 (CAMK2D) S319 HPRD 18691976, 17192257, 20068231
Q13557-12 (CAMK2D) T331 HPRD 20166139, 18691976, 17192257
Q13557-8 (CAMK2D) S333 HPRD 19413330, 18691976, 17192257
Q13557-12 (CAMK2D) S334 HPRD 18691976, 17192257
Q13557-1 (CAMK2D) T337 HPRD 20166139, 18691976, 17192257, ...18452278
Q14524 (SCN5A) S516 neXtProt   PhosphoSitePlus   Signor 22514276
Q14524 (SCN5A) T594 neXtProt   PhosphoSitePlus   Signor 22514276
Q14571 (ITPR2) S150 neXtProt 23019322
Q14654 (KCNJ11) T224 PhosphoSitePlus   Signor 24101510, 23223335
Q16695 (H3-4) S11 neXtProt 23804765
Q8WYL5 (SSH1) S937 neXtProt 22270398
Q8WYL5 (SSH1) S978 neXtProt 22270398
Q8WZ42 (TTN) S4062 neXtProt 23283722
Q8WZ42 (TTN) S11878 PhosphoSitePlus 23220127
Q8WZ42 (TTN) S12022 neXtProt   PhosphoSitePlus 23220127, 23283722
Q92736 (RYR2) S2814 neXtProt 14556649, 20479242, 17234969
Q9UQL6 (HDAC5) S498 neXtProt 21998325, 22360269
PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000029002 (hHDAC4/iso:1/Phos:1) pS210,pS246 PR:Q13557-3 (hCAMK2D/iso:hDelta 3) PRO 17179159


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046557 (hCAMK2D/InitMet-/Phos:1) pT287 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31948 (STIP1) S189 Q13557 (CAMK2D) unknown eFIP 18486612


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 P3 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K138 N138 Biomuta DOID:363 / uterine cancer [ tcga ]
K227 Q227 Biomuta DOID:263 / kidney cancer [ cosmic ]
T254 S254 Biomuta DOID:11934 / head and neck cancer [ tcga ]
T254 N254 Biomuta DOID:363 / uterine cancer [ tcga ]
T307 I307 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
T311 A311 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S441 I441 Biomuta DOID:1324 / lung cancer [ tcga ]