iPTMnet Report Q13555 CAMK2G

Protein Information

UniProt AC / UniProt ID	Q13555 / KCC2G_HUMAN
Protein Name	Calcium/calmodulin-dependent protein kinase type II subunit gamma
Gene Name	Name: CAMK2G Synonyms:CAMK,CAMK-II,CAMKG;
Organism	Homo sapiens (Human)

PRO ID	PR:Q13555 DAG View
PRO Name	calcium/calmodulin-dependent protein kinase type II subunit gamma (human)
Definition	A calcium/calmodulin-dependent protein kinase type II subunit gamma that is encoded in the genome of human.
Short Label	hCAMK2G
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q13555 (CAMK2G) as Substrate

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
Y14	Phosphorylation		score1	PhosphoSitePlus
K22	Ubiquitination		score1	PhosphoSitePlus
S26	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	23289753
K34	Ubiquitination		score1	PhosphoSitePlus
T35	Phosphorylation		score1	PhosphoSitePlus
K43	Ubiquitination		score1	PhosphoSitePlus
K57	Acetylation		score1	PhosphoSitePlus
K57	Ubiquitination		score1	PhosphoSitePlus
K69	Ubiquitination		score1	PhosphoSitePlus
S79	Phosphorylation		score1	PhosphoSitePlus
S114	Phosphorylation		score1	PhosphoSitePlus
K138	Ubiquitination		score1	PhosphoSitePlus
S146	Phosphorylation		score1	PhosphoSitePlus
K227	Acetylation		score1	PhosphoSitePlus
K227	Ubiquitination		score1	PhosphoSitePlus
Y231	Phosphorylation		score1	PhosphoSitePlus
S235	Phosphorylation		score1	PhosphoSitePlus
K246	Ubiquitination		score1	PhosphoSitePlus
T254	Phosphorylation		score1	PhosphoSitePlus
K259	Ubiquitination		score1	PhosphoSitePlus
K268	Ubiquitination		score1	PhosphoSitePlus
C273	S-Nitrosylation		score0	dbSNO	26338901
S276	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976
S280	Phosphorylation	Q13555 (CAMK2G)	score4	PhosphoSitePlus RLIMS-P	7654190, 23289753
T287	Phosphorylation	Q13555 (CAMK2G)	score4	HPRD neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	16690701, 29737974, 14761894, ...23613689, 18691976, 23186163, 27147617, 23289753, 18088385, 26361740, 32439852, 14722083, 32863217, 34088288, 14565989, 19369195, 17081983, 29391954, 29059213, 18669648, 26791827
K299	Methylation		score1	PhosphoSitePlus
K301	Methylation		score1	PhosphoSitePlus
T306	Phosphorylation		score4	HPRD PhosphoSitePlus RLIMS-P	18691976, 2162839, 20668654, ...9744891, 20058876, 30184290, 22427672
T307	Phosphorylation		score4	PhosphoSitePlus RLIMS-P	30184290, 20668654
S311	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	18691976, 20068231, 19369195
S315	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	18691976, 17192257, 20068231
S319	Phosphorylation	Q13555 (CAMK2G)	score4	HPRD phospho.ELM PhosphoSitePlus	18691976, 17192257, 7654190
S325	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	18691976, 19369195
S334	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	30184290
S336	Phosphorylation		score0	RLIMS-P	16278289
V338	Phosphorylation		score1	UniProt	18691976
N346	Phosphorylation		score1	UniProt	18691976, 19369195
S349	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976
S352	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976, 19369195
T382	Phosphorylation		score1	PhosphoSitePlus
S384	Phosphorylation		score1	PhosphoSitePlus
T388	Phosphorylation		score1	PhosphoSitePlus
S419	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976, 23186163, 24275569, ...19369195

Site	PTM Type	Score	Source	PMID
S276	Phosphorylation	score0	HPRD	18691976
T287	Phosphorylation	score0	HPRD	18691976, 18669648, 17081983
T306	Phosphorylation	score0	HPRD	18691976, 20058876
S311	Phosphorylation	score0	HPRD	18691976, 20068231
S315	Phosphorylation	score0	HPRD	18691976, 20068231
S319	Phosphorylation	score0	HPRD	18691976
S325	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976
T341	Phosphorylation	score0	HPRD	18691976
S347	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976
T348	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976
S350	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976, 20068231

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S325	Phosphorylation		score1	PhosphoSitePlus
	S333	Phosphorylation		score1	PhosphoSitePlus

Site	PTM Type	Score	Source	PMID
S276	Phosphorylation	score0	HPRD	18691976
T287	Phosphorylation	score0	HPRD	18691976, 18669648, 17081983
S311	Phosphorylation	score0	HPRD	18691976, 20068231
S315	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976
S320	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976
S321	Phosphorylation	score1	PhosphoSitePlus
S325	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976
S346	Phosphorylation	score0	HPRD	20068231
S355	Phosphorylation	score1	PhosphoSitePlus
S356	Phosphorylation	score1	PhosphoSitePlus
S357	Phosphorylation	score1	PhosphoSitePlus
S358	Phosphorylation	score1	PhosphoSitePlus
T373	Phosphorylation	score0	HPRD	18691976
S379	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976
T380	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976
S382	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976, 20068231
T386	Phosphorylation	score1	PhosphoSitePlus

Site	PTM Type	Score	Source
S315	Phosphorylation	score1	PhosphoSitePlus
S320	Phosphorylation	score1	PhosphoSitePlus
S321	Phosphorylation	score1	PhosphoSitePlus
S325	Phosphorylation	score1	PhosphoSitePlus
T403	Phosphorylation	score1	PhosphoSitePlus
S405	Phosphorylation	score1	PhosphoSitePlus

Site	PTM Type	Score	Source
S325	Phosphorylation	score1	PhosphoSitePlus
S333	Phosphorylation	score1	PhosphoSitePlus
S338	Phosphorylation	score1	PhosphoSitePlus
T344	Phosphorylation	score1	PhosphoSitePlus
S356	Phosphorylation	score1	PhosphoSitePlus
T357	Phosphorylation	score1	PhosphoSitePlus
S359	Phosphorylation	score1	PhosphoSitePlus
T376	Phosphorylation	score1	PhosphoSitePlus
S380	Phosphorylation	score1	PhosphoSitePlus

Q13555 (CAMK2G) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
O60266-1 (ADCY3)	S1076	score3	HPRD Signor	8798667, 9768837
P00533-1 (EGFR)	S1070	score2	HPRD	10347170, 16799092, 1309762
P00533 (EGFR)	S1071	score3	HPRD Signor	10347170, 1309762
P07101-2 (TH)	S19	score2	HPRD	11359875, 6150037
P10276 (RARA)	T210	score2	neXtProt	17431504
P17600-2 (SYN1)	S568	score1	HPRD	3118371
P17600-2 (SYN1)	S605	score1	HPRD	3118371
P18846-1 (ATF1)	S63	score2	HPRD	8663317, 20068231
P21333-2 (FLNA)	S2515	score1	HPRD	11290523
P21817-1 (RYR1)	S2843	score2	HPRD	8380342, 14532276
P28329-3 (CHAT)	T456	score1	HPRD	12486117
P28329-1 (CHAT)	T574	score1	HPRD	12486117
P35270 (SPR)	S213	score1	HPRD	11825621
P40763 (STAT3)	S727	score2	neXtProt	18483256
P42224-1 (STAT1)	S727	score2	HPRD	18691976, 15322115, 20058876, ...7543024, 18452278, 11839738, 11972023, 18669648, 14963018, 7690989, 9355737, 12637327, 20068231
P42261-1 (GRIA1)	S645	score1	HPRD	7877986
P42261-1 (GRIA1)	S849	score2	HPRD	9407043, 12609872
P48058-1 (GRIA4)	S862	score1	HPRD	10366608
P55042 (RRAD)	S273	score2	HPRD	7876254, 9677319
Q01970-1 (PLCB3)	S537	score0	HPRD	19651622, 18669648, 15302935, ...20068231
Q03060-16 (CREM)	S87	score1	HPRD	8404858
Q13555 (CAMK2G)	S280	score2	PhosphoSitePlus	7654190
Q13555 (CAMK2G)	T287	score4	neXtProt UniProt	14722083, 16690701, 23289753
Q13555 (CAMK2G)	S319	score2	PhosphoSitePlus	7654190
Q15121-1 (PEA15)	S116	score2	HPRD	19413330, 18578522, 17287340, ...18212344, 18767875, 19664995, 18452278, 19651622, 18669648, 12808093, 20166139, 9721757, 20068231
Q15746-1 (MYLK)	S1760	score2	HPRD	10748018, 18088087, 2160950
Q92934 (BAD)	S134	score2	neXtProt	22103330
Q9UQL6 (HDAC5)	S259	score1	Signor	11114197
Q9UQL6 (HDAC5)	S498	score1	Signor	11114197
Q9Y618 (NCOR2)	S2407	score1	Signor	22888005

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000046558 (hCAMK2G/Phos:1)	pT287		PRO

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	P16949 (STMN1)	S16	Q13555 (CAMK2G)	inhibited_association	eFIP	26317901

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
T306	K306	Biomuta	DOID:3571 / liver cancer [ cosmic ]
T306	M306	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S325	L325	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S346	L346	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q13555 (CAMK2G)

Protein Information

Interactive Sequence View

Q13555 (CAMK2G) as Substrate

Q13555 (CAMK2G) as PTM Enzyme

Proteoforms

PTM-dependent PPI

PTM sites affected in variants