iPTMnet Report for Q13554 (CAMK2B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13554 / KCC2B_HUMAN
Protein Name Calcium/calmodulin-dependent protein kinase type II subunit beta
Gene Name Name: CAMK2B
Synonyms:CAM2,CAMK2,CAMKB;
Organism Homo sapiens (Human)

PRO ID PR:Q13554
DAG View
PRO Name calcium/calmodulin-dependent protein kinase type II subunit beta (human)
Definition A calcium/calmodulin-dependent protein kinase type II subunit beta that is encoded in the genome of human.
Short Label hCAMK2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13554 (CAMK2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K33 Acetylation PhosphoSitePlus
K57 Acetylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
K227 Acetylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
Y231 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
T287 Phosphorylation neXtProt   PRO   PhosphoSitePlus   UniProt 14722083, 16690701
T287 Phosphorylation Q13554 (CAMK2B) neXtProt   UniProt 14722083, 16690701
K299 Methylation PhosphoSitePlus
K301 Methylation PhosphoSitePlus
T306 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
T320 O-Glycosylation GlyGen 23301498, 24077098, 28657654, ...22564745
T321 O-Glycosylation GlyGen 23301498, 24077098, 28657654, ...22564745
T325 O-Glycosylation GlyGen 28657654
T328 O-Glycosylation GlyGen 28657654
T328 Phosphorylation PhosphoSitePlus
T333 O-Glycosylation GlyGen 28657654
K342 Acetylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
T400 Phosphorylation PhosphoSitePlus
T401 Phosphorylation PhosphoSitePlus   UniProt 24275569
S423 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
T463 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
T506 Phosphorylation PhosphoSitePlus
S522 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T287 Phosphorylation HPRD 3417668, 2842767, 14565989
T287 Phosphorylation Q13554 (CAMK2B) HPRD 3417668, 2842767, 14565989
S315 Phosphorylation HPRD 20068231
T320 Phosphorylation HPRD 20068231
S327 Phosphorylation HPRD 20068231
T381 Phosphorylation HPRD 20068231
T382 Phosphorylation HPRD 20068231
S394 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T287 Phosphorylation HPRD 3417668, 2842767, 14565989
T287 Phosphorylation Q13554 (CAMK2B) HPRD 3417668, 2842767, 14565989
S315 Phosphorylation HPRD 20068231
T320 Phosphorylation HPRD 20068231
S327 Phosphorylation HPRD 20068231
T381 Phosphorylation HPRD 20068231
T382 Phosphorylation HPRD 20068231
S394 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T287 Phosphorylation HPRD 3417668, 2842767, 14565989
T287 Phosphorylation Q13554 (CAMK2B) HPRD 3417668, 2842767, 14565989
T311 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T287 Phosphorylation HPRD 3417668, 2842767, 14565989
T287 Phosphorylation Q13554 (CAMK2B) HPRD 3417668, 2842767, 14565989
S315 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T287 Phosphorylation HPRD 3417668, 2842767, 14565989
T287 Phosphorylation Q13554 (CAMK2B) HPRD 3417668, 2842767, 14565989
T357 Phosphorylation HPRD 20068231
T358 Phosphorylation HPRD 20068231
S370 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T287 Phosphorylation HPRD   PhosphoSitePlus 3417668, 14565989, 2842767
T287 Phosphorylation Q13554 (CAMK2B) HPRD 3417668, 2842767, 14565989
S315 Phosphorylation HPRD 20068231
T320 Phosphorylation HPRD 20068231
S327 Phosphorylation HPRD 20068231
T357 Phosphorylation HPRD 20068231
T358 Phosphorylation HPRD 20068231
S370 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T287 Phosphorylation HPRD 3417668, 2842767, 14565989
T287 Phosphorylation Q13554 (CAMK2B) HPRD 3417668, 2842767, 14565989
Site PTM Type PTM Enzyme Score Source PMID
T287 Phosphorylation HPRD 3417668, 2842767, 14565989
T287 Phosphorylation Q13554 (CAMK2B) HPRD 3417668, 2842767, 14565989
S315 Phosphorylation HPRD   PhosphoSitePlus 18691976
T356 Phosphorylation HPRD 20068231
T357 Phosphorylation HPRD 20068231
S369 Phosphorylation HPRD 20068231


Q13554 (CAMK2B) as PTM Enzyme



Substrate Site Score Source PMID
O14490-2 (DLGAP1) S349 PhosphoSitePlus 23143515
O14490-2 (DLGAP1) S393 PhosphoSitePlus 23143515
P14921-1 (ETS1) S251 HPRD 12475968
P14921-1 (ETS1) S257 HPRD 12475968
P14921-1 (ETS1) S282 HPRD 12475968
P14921-1 (ETS1) S285 HPRD 12475968
P16949 (STMN1) S16 PhosphoSitePlus   Signor 9686569
P26678 (PLN) T17 neXtProt 16690701
P35222 (CTNNB1) T332 Signor 24117889
P35222 (CTNNB1) T472 Signor 24117889
P35222 (CTNNB1) S552 Signor 24117889
P42224 (STAT1) S727 Signor 17502367
P49840 (GSK3A) S21 Signor 20841359
Q01970-1 (PLCB3) S537 HPRD 19651622, 18669648, 15302935, ...20068231
Q12879-1 (GRIN2A) S1291 HPRD 12147342
Q13131 (PRKAA1) T183 PhosphoSitePlus   Signor 15980064, 21680840
Q13224 (GRIN2B) S383 HPRD 8940188
Q13224 (GRIN2B) S1303 HPRD 11306676, 8940188, 12147342
Q13554-8 (CAMK2B) T287 HPRD   neXtProt   UniProt 3417668, 2842767, 16690701, ...14565989, 14722083
Q9NQC7 (CYLD) S362 Signor 24614225
Q9NQC7 (CYLD) S418 Signor 24614225
Q9NQC7 (CYLD) S772 Signor 24614225


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046556 (hCAMK2B/Phos:1) pT287 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K138 N138 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T287 I287 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S315 L315 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K342 N342 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S423 L423 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S461 L461 Biomuta DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic, cosmic, cosmic, cosmic, cosmic ] DOID:8618 / oral cavity cancer [ cosmic, cosmic, cosmic, cosmic, cosmic ] DOID:11934 / head and neck cancer [ icgc, icgc, icgc, icgc, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]