iPTMnet Report for Q13547 (HDAC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13547 / HDAC1_HUMAN
Protein Name Histone deacetylase 1
Gene Name Name: HDAC1
Synonyms:RPD3L1;
Organism Homo sapiens (Human)

PRO ID PR:Q13547
DAG View
PRO Name histone deacetylase 1 (human)
Definition A histone deacetylase 1 that is encoded in the genome of human.
Short Label hHDAC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13547 (HDAC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Ubiquitination PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
R36 Methylation PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus   RLIMS-P 33976119
K74 Acetylation PhosphoSitePlus   UniProt 19608861
K74 Ubiquitination PhosphoSitePlus
Y87 Phosphorylation PhosphoSitePlus   RLIMS-P 33976119
S88 Phosphorylation PhosphoSitePlus
K89 Acetylation PhosphoSitePlus
K89 Methylation PhosphoSitePlus
K89 Sumoylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
T114 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...27060025, 32522876, 34019948, 20305658, 32119511, 28510447, 12150998
K123 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
S145 O-Glycosylation GlyGen 27060025
C151 Methylation IEDB 31844290
K200 Ubiquitination PhosphoSitePlus
Y204 Phosphorylation PhosphoSitePlus   RLIMS-P 33976119
K218 Acetylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K220 Acetylation PhosphoSitePlus   UniProt 19608861
K220 Ubiquitination PhosphoSitePlus
Y221 Phosphorylation HPRD   PhosphoSitePlus 15592455, 20068231
Y222 Phosphorylation HPRD 20068231
Y226 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y237 Phosphorylation HPRD 20068231
K242 Ubiquitination PhosphoSitePlus
S263 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...27060025, 32522876, 34019948, 20305658, 32119511, 28510447, 12150998
C273 Methylation IEDB 31844290
K279 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
Y333 Phosphorylation PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
K342 Sumoylation PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus   RLIMS-P 33976119
K361 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
R365 Methylation PhosphoSitePlus
S393 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 18491316, ...23186163, 17081983, 18691976, 20230923, 19664995, 18452278, 19651622, 18669648, 19690332, 24275569, 17487921, 19415658, 20068231
S406 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 19007248, 26467746
S409 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S410 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19691289
K412 Acetylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
S421 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 21406692, 23186163, ...17081983, 17643391, 23835259, 18767875, 11602581, 24668294, 18318008, 19651622, 17022812, 18669648, 19415658, 27669993, 20166139, 17287340, 18452278, 19690332, 20068231
S421 Phosphorylation P19784 (CSNK2A2) HPRD   Signor 19413330, 17287340, 18767875, ...11602581, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S421 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus   Signor 19413330, 17287340, 18767875, ...11602581, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S423 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23835259, 21406692, 23186163, ...17081983, 17643391, 18767875, 11602581, 19413330, 18318008, 19651622, 17022812, 18669648, 20166139, 17287340, 18452278, 19415658, 20068231
S423 Phosphorylation P19784 (CSNK2A2) HPRD   Signor 19413330, 17287340, 18767875, ...11602581, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S423 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus   Signor 19413330, 17287340, 18767875, ...11602581, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
K432 Acetylation PhosphoSitePlus
K432 Methylation PhosphoSitePlus   UniProt 18438403
S434 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
K438 Acetylation PhosphoSitePlus
K439 Acetylation PhosphoSitePlus
K441 Acetylation PhosphoSitePlus
K444 Sumoylation PhosphoSitePlus
T445 Phosphorylation PhosphoSitePlus
K457 Sumoylation PhosphoSitePlus
K476 Sumoylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q01543 (FLI1) T312 Q13547 (HDAC1) unknown eFIP 24058639
Phosphorylation Q01826 (SATB1) S185 Q13547 (HDAC1) increased_association eFIP 20694677
Phosphorylation Q04206 (RELA) T435 Q13547 (HDAC1) decreased_association eFIP 22715377
Phosphorylation Q13547 (HDAC1) Y72 P00533 (EGFR) unknown eFIP 33976119


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O60566 (hBUB1B) Interaction PR:Q13547 (hHDAC1) PRO
PR:P29590-5 (hPML/iso:5) Interaction PR:Q13547 (hHDAC1) PRO 11259576


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K31 T31 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R36 L36 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T114 I114 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
C151 S151 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y204 S204 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y222 D222 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y358 N358 Biomuta DOID:2998 / testicular cancer [ cosmic ]
R365 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
R365 Q365 Biomuta DOID:1612 / breast cancer [ cosmic ]
S423 F423 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S435 F435 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]