Protein Information

Cytoscape View

UniProt AC / UniProt ID Q13546 / RIPK1_HUMAN
Protein Name Receptor-interacting serine/threonine-protein kinase 1
Gene Name Name: RIPK1
Organism Homo sapiens (Human)

PRO ID PR:Q13546
DAG View
PRO Name receptor-interacting serine/threonine-protein kinase 1 (human)
Definition A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human.
Short Label hRIPK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q13546 (RIPK1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
S6 Phosphorylation PhosphoSitePlus   UniProt 18408713
K13 Ubiquitination PhosphoSitePlus
S14 Phosphorylation Q13546 (RIPK1) PhosphoSitePlus 18408713
S15 Phosphorylation Q13546 (RIPK1) PhosphoSitePlus 18408713
S20 Phosphorylation Q13546 (RIPK1) PhosphoSitePlus 18408713
S25 Phosphorylation PhosphoSitePlus   UniProt 18408713, 30988283
S32 Phosphorylation PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S161 Phosphorylation Q13546 (RIPK1) PhosphoSitePlus   RLIMS-P 18408713, 31521607, 28176780
K163 Ubiquitination PhosphoSitePlus
S166 Phosphorylation Q13546 (RIPK1) PhosphoSitePlus   RLIMS-P   UniProt 31534131, 29844315, 18408713, ...32398349, 33469115, 30666647, 30349023, 32366830, 28506461, 29383104, 33608503, 31827280, 30442947, 33542218, 29440439, 28842570
K167 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus   UniProt 18408713
K306 Ubiquitination PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
S320 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18408713, 18669648, 28539327, ...23186163
S330 O-Glycosylation GlyGen 23301498, 32119511, 28657654, ...29237092, 30059200
S330 Phosphorylation PhosphoSitePlus
S331 O-Glycosylation GlyGen 23301498, 32119511, 28657654, ...29237092, 30059200
S331 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus   UniProt 18408713
S335 Phosphorylation PhosphoSitePlus
T337 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S345 Phosphorylation PhosphoSitePlus
S346 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S357 Phosphorylation PhosphoSitePlus   RLIMS-P 32944633, 32320653, 32578493
K377 Ubiquitination PhosphoSitePlus   UniProt 16603398
Y384 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15144186
Y387 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
S389 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
S416 Phosphorylation PhosphoSitePlus
Y426 Phosphorylation PhosphoSitePlus
Y463 Phosphorylation PhosphoSitePlus
Y469 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
R477 Methylation PhosphoSitePlus
T483 Phosphorylation PhosphoSitePlus
R487 Methylation PhosphoSitePlus
Y490 Phosphorylation PhosphoSitePlus
K530 Acetylation PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
K642 Acetylation PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
K648 Acetylation PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S320 Phosphorylation HPRD 18767875, 18669648
T337 Phosphorylation HPRD 18669648
S346 Phosphorylation HPRD 18669648
Y384 Phosphorylation HPRD 15144186
Y387 Phosphorylation HPRD 15144186
S389 Phosphorylation HPRD 15144186

Q13546 (RIPK1) as PTM Enzyme

Substrate Site Score Source PMID
Q13233 (MAP3K1) S970 Signor 11369754
Q13546 (RIPK1) S14 PhosphoSitePlus 18408713
Q13546 (RIPK1) S15 PhosphoSitePlus 18408713
Q13546 (RIPK1) S20 PhosphoSitePlus 18408713
Q13546 (RIPK1) S161 PhosphoSitePlus 18408713
Q13546 (RIPK1) S166 PhosphoSitePlus   UniProt 18408713, 29440439
Q5VWQ8 (DAB2IP) S728 PhosphoSitePlus   Signor 27858941, 17389591


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049045 (hRIPK1/PhosSer+) p PRO

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13546 (RIPK1) S166 Q9Y572 (RIPK3) unknown eFIP 28842570
Phosphorylation Q13546 (RIPK1) S320 Q13158 (FADD) inhibited_association eFIP 28539327

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036649 (hRIPK1/iso:1/Ubiq:1) Interaction PR:Q8C669 (mPELI1) PRO 19734906

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 A6 Biomuta DOID:3571 / liver cancer [ icgc ]
S14 A14 Biomuta DOID:3070 / malignant glioma [ cosmic ]
K153 N153 Biomuta DOID:1115 / sarcoma [ tcga ]
K167 E167 Biomuta DOID:363 / uterine cancer [ tcga ]
K284 T284 Biomuta DOID:363 / uterine cancer [ tcga ]
S296 N296 Biomuta DOID:363 / uterine cancer [ tcga ]
T337 I337 Biomuta DOID:10534 / stomach cancer [ tcga ]
S346 F346 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y384 H384 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S416 F416 Biomuta DOID:363 / uterine cancer [ tcga ]
Y463 F463 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y469 C469 Biomuta DOID:3571 / liver cancer [ icgc, tcga ]
K571 R571 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K627 N627 Biomuta DOID:363 / uterine cancer [ tcga ]