iPTMnet Report for Q13542 (EIF4EBP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13542 / 4EBP2_HUMAN
Protein Name Eukaryotic translation initiation factor 4E-binding protein 2
Gene Name Name: EIF4EBP2
Organism Homo sapiens (Human)

PRO ID PR:Q13542
DAG View
PRO Name eukaryotic translation initiation factor 4E-binding protein 2 (human)
Definition A eukaryotic translation initiation factor 4E-binding protein 2 that is encoded in the genome of human.
Short Label hEIF4EBP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13542 (EIF4EBP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
R15 Methylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
Y34 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19664995
T36 Phosphorylation HPRD   PhosphoSitePlus 19664995
T37 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 25533957, 32561718, ...19664995, 18669648, 18491316, 28068774, 25822952, 19690332
T41 Phosphorylation HPRD   PhosphoSitePlus 19413330
S44 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648
T45 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648
T46 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 25533957, 19664995, 32561718, ...18669648, 18491316, 28068774, 25822952
T50 Phosphorylation PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 25533957, 32561718
T70 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 25533957, 32561718
S83 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 25533957, 32561718


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13542 (EIF4EBP2) T37 P06730 (EIF4E) decreased_association eFIP 25822952


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S65 Y65 Biomuta DOID:9256 / colorectal cancer [ icgc ]