iPTMnet Report for Q13535 (ATR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13535 / ATR_HUMAN
Protein Name Serine/threonine-protein kinase ATR
Gene Name Name: ATR
Synonyms:FRP1;
Organism Homo sapiens (Human)

PRO ID PR:Q13535
DAG View
PRO Name serine/threonine-protein kinase ATR (human)
Definition A serine/threonine-protein kinase ATR that is encoded in the genome of human.
Short Label hATR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13535 (ATR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K32 Ubiquitination PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
S95 Phosphorylation RLIMS-P 31615875
R177 Methylation PhosphoSitePlus
Y291 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20798688
Y291 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor 20798688
K297 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
Y310 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20798688
Y310 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor 20798688
S428 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 18691976, 22957056, 26919204, ...19482673, 28698766, 26387736, 26683224, 26124337, 24804719, 24153426, 20084458, 30245854, 23344034, 21144835, 24553354, 28412751, 27656146, 32984322
S428 Phosphorylation P06493 (CDK1) PhosphoSitePlus 26387736
S435 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 33202302, 27683220, ...28916831, 26168232, 28094871, 24950377
S435 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 24950377
S436 Phosphorylation PhosphoSitePlus   UniProt 23186163
S437 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
S464 Phosphorylation IEDB   PhosphoSitePlus 27869121
T533 Phosphorylation PhosphoSitePlus
C607 Methylation IEDB 31844290
K695 Ubiquitination PhosphoSitePlus
K746 Methylation PhosphoSitePlus
K746 Ubiquitination PhosphoSitePlus
K759 Methylation PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
K791 Ubiquitination PhosphoSitePlus
K818 Ubiquitination PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
K866 Ubiquitination PhosphoSitePlus
K918 Ubiquitination PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
K921 Ubiquitination PhosphoSitePlus
T952 Phosphorylation PhosphoSitePlus
K1005 Ubiquitination PhosphoSitePlus
S1007 Phosphorylation PhosphoSitePlus
K1019 Ubiquitination PhosphoSitePlus
Y1122 Phosphorylation PhosphoSitePlus
S1140 Phosphorylation PhosphoSitePlus
K1165 Ubiquitination PhosphoSitePlus
K1173 Acetylation PhosphoSitePlus
K1173 Ubiquitination PhosphoSitePlus
K1185 Ubiquitination PhosphoSitePlus
T1275 Phosphorylation PhosphoSitePlus
K1308 Ubiquitination PhosphoSitePlus
S1333 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 24901225, 10608806
S1333 Phosphorylation Q13535 (ATR) neXtProt 10608806
K1467 Ubiquitination PhosphoSitePlus
K1475 Ubiquitination PhosphoSitePlus
K1476 Ubiquitination PhosphoSitePlus
T1566 Phosphorylation PhosphoSitePlus
T1578 Phosphorylation PhosphoSitePlus
T1589 Phosphorylation PhosphoSitePlus
K1600 Ubiquitination PhosphoSitePlus
K1613 Ubiquitination PhosphoSitePlus
S1645 Phosphorylation PhosphoSitePlus
K1666 Ubiquitination PhosphoSitePlus
K1697 Ubiquitination PhosphoSitePlus
K1703 Ubiquitination PhosphoSitePlus
C1721 Methylation IEDB 31844290
K1824 Ubiquitination PhosphoSitePlus
S1871 Phosphorylation PhosphoSitePlus
S1876 Phosphorylation PhosphoSitePlus
K1897 Ubiquitination PhosphoSitePlus
K1912 Ubiquitination PhosphoSitePlus
K1933 Ubiquitination PhosphoSitePlus
T1989 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 25965828, 21777809, 26684013, ...31266951, 18691976, 23186163, 32675286, 27839769, 31114877, 25249630, 26783066, 30839063, 33820915, 21705319, 31759252, 28264028, 29209046, 31529615, 15302935, 27538817, 18669648, 32741974, 29163782, 23897887
T1989 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus 21777809
K1994 Ubiquitination PhosphoSitePlus
K2026 Ubiquitination PhosphoSitePlus
K2048 Ubiquitination PhosphoSitePlus
S2075 O-Glycosylation GlyGen 30379171
K2106 Ubiquitination PhosphoSitePlus
K2121 Ubiquitination PhosphoSitePlus
S2186 Phosphorylation PhosphoSitePlus
Y2187 Phosphorylation PhosphoSitePlus
K2200 Ubiquitination PhosphoSitePlus
K2210 Ubiquitination PhosphoSitePlus
K2221 Ubiquitination PhosphoSitePlus
K2228 Ubiquitination PhosphoSitePlus
S2313 Phosphorylation PhosphoSitePlus
K2347 Ubiquitination PhosphoSitePlus
K2397 Ubiquitination PhosphoSitePlus
K2404 Ubiquitination PhosphoSitePlus
S2414 O-Glycosylation GlyGen 30379171
K2420 Ubiquitination PhosphoSitePlus
K2567 Ubiquitination PhosphoSitePlus
K2574 Ubiquitination PhosphoSitePlus
K2587 Ubiquitination PhosphoSitePlus
K2589 Ubiquitination PhosphoSitePlus
K2604 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S428 Phosphorylation HPRD 18691976
S435 Phosphorylation HPRD 19651622, 18691976, 20068231
S436 Phosphorylation HPRD 19651622, 18691976, 20068231
S437 Phosphorylation HPRD 19651622
S480 Phosphorylation HPRD 10608806, 11418864
S480 Phosphorylation O75943 (RAD17) HPRD 10608806, 11418864
S549 Phosphorylation HPRD 10608806, 11418864
S549 Phosphorylation O75943 (RAD17) HPRD 10608806, 11418864
S919 Phosphorylation HPRD 17924679
S1154 Phosphorylation HPRD 20068231
S1875 Phosphorylation HPRD 18691976
T1989 Phosphorylation HPRD 19413330, 18691976, 18669648, ...15302935


Q13535 (ATR) as PTM Enzyme



Substrate Site Score Source PMID
O00203 (AP3B1) S1092 neXtProt 10608806
O14757 (CHEK1) S296 PhosphoSitePlus 19351595
O14757-1 (CHEK1) S317 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 18691976, 19351595, 15775976, ...11252893, 10859164, 18669648, 15665856, 11390642, 18723495, 16293623
O14757-1 (CHEK1) S345 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19351595, 15775976, 15533933, ...19477925, 10859164, 22357623, 15665856, 21777809, 11390642, 19828454
O15360 (FANCA) S1449 neXtProt   PhosphoSitePlus   Signor 19109555
O43542 (XRCC3) S225 neXtProt   PhosphoSitePlus   Signor 23438602
O60934 (NBN) S343 neXtProt   PhosphoSitePlus   Signor 17526493, 18644472
O60934 (NBN) S615 PhosphoSitePlus 18077418
O75717 (WDHD1) T826 RLIMS-P+   Signor 26082189
O75943-3 (RAD17) S470 HPRD 10608806, 11418864
O75943-3 (RAD17) S480 HPRD 10608806, 11418864
O75943-4 (RAD17) S549 HPRD 10608806, 11418864
O75943-4 (RAD17) S559 HPRD 10608806, 11418864
O75943-2 (RAD17) S635 HPRD 10608806, 11418864
O75943-2 (RAD17) S645 HPRD 10608806, 11418864
O75943 (RAD17) S646 HPRD   neXtProt   PhosphoSitePlus   Signor 10608806, 11418864, 11687627
O75943-1 (RAD17) S656 HPRD   neXtProt   PhosphoSitePlus   Signor 10608806, 11418864, 11687627, ...21777809
O94880 (PHF14) S294 PhosphoSitePlus 18077418
O96017-1 (CHEK2) S19 HPRD 10973490
O96017-1 (CHEK2) T26 HPRD 10973490, 12493754, 12024051
O96017-9 (CHEK2) S28 HPRD 10973490, 12024051
O96017-12 (CHEK2) S33 HPRD 10973490
O96017-9 (CHEK2) S35 HPRD 10973490
O96017-9 (CHEK2) S50 HPRD 10973490
O96017 (CHEK2) T68 PhosphoSitePlus   Signor 10973490, 15533933
P04637 (TP53) S15 HPRD   PhosphoSitePlus   RLIMS-P+   Signor 11551930, 11865061, 15806145, ...10673501, 15533933, 19477925, 10597277, 15159397, 15322239, 9925639, 11711532, 16293623, 11709713, 15226429, 17977830, 9765199, 19828454
P04637-1 (TP53) T18 HPRD 10747897, 10673501, 11551930, ...10951572, 11709713, 11883897
P04637-1 (TP53) S20 HPRD 10673501, 11551930, 11709713
P04637 (TP53) S37 HPRD   neXtProt   PhosphoSitePlus 9925639, 10608806, 11709713, ...10673501
P06748 (NPM1) S125 neXtProt   PhosphoSitePlus 15082766
P08047 (SP1) S101 PhosphoSitePlus 18619531
P15927 (RPA2) T21 neXtProt   PhosphoSitePlus 17035231
P15927 (RPA2) S23 RLIMS-P+ 26271993
P15927 (RPA2) S29 RLIMS-P+ 26271993
P15927 (RPA2) S33 neXtProt   PhosphoSitePlus   Signor 19843584, 17035231, 23684611
P15927 (RPA2) S52 neXtProt   PhosphoSitePlus 10608806, 17035231
P15927 (RPA2) S72 PhosphoSitePlus 17035231
P15927 (RPA2) S174 PhosphoSitePlus 17035231
P16220 (CREB1) S107 Signor 15073328
P18583 (SON) S1216 neXtProt 10608806
P23025 (XPA) S173 HPRD   PhosphoSitePlus   Signor 16540648
P23025 (XPA) S196 HPRD   PhosphoSitePlus   Signor 16540648, 23178497, 30327428, ...19586908
P23508 (MCC) S118 Signor 21779472
P23508 (MCC) S120 Signor 21779472
P25205 (MCM3) S535 PhosphoSitePlus 15210935
P27707 (DCK) S74 PhosphoSitePlus 26620371
P28340 (POLD1) S717 neXtProt 10608806
P30307 (CDC25C) S216 RLIMS-P+ 28264028
P35568 (IRS1) S270 PhosphoSitePlus 18077418
P38398-6 (BRCA1) T291 HPRD 11114888
P38398-6 (BRCA1) S320 HPRD 11114888, 15159397
P38398-3 (BRCA1) S353 HPRD 11114888
P38398-8 (BRCA1) S1096 HPRD 11114888
P38398-1 (BRCA1) S1143 HPRD   neXtProt   PhosphoSitePlus   Signor 11114888
P38398-8 (BRCA1) S1233 HPRD 11114888
P38398 (BRCA1) S1280 HPRD   neXtProt   PhosphoSitePlus   Signor 11114888
P38398 (BRCA1) S1298 neXtProt 10608806
P38398-8 (BRCA1) T1347 HPRD 11114888
P38398-8 (BRCA1) S1376 HPRD 11114888
P38398-1 (BRCA1) S1387 HPRD   neXtProt   Signor 11114888, 10608806, 11278964
P38398 (BRCA1) T1394 HPRD   Signor 11114888
P38398-8 (BRCA1) S1410 HPRD 11114888
P38398-1 (BRCA1) S1423 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11114888, 15159397, 11278964
P38398 (BRCA1) S1457 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11114888, 11278964
P38398 (BRCA1) S1466 neXtProt 10608806
P38398 (BRCA1) S1524 HPRD   phospho.ELM   PhosphoSitePlus 11278964, 20068231
P39880 (CUX1) S1357 PhosphoSitePlus 18077418
P40692 (MLH1) S406 PhosphoSitePlus 21864706
P42771 (CDKN2A) S7 PhosphoSitePlus 21270107
P42771 (CDKN2A) S8 PhosphoSitePlus 21270107
P42771 (CDKN2A) S140 PhosphoSitePlus 21270107
P42771 (CDKN2A) S152 PhosphoSitePlus 21270107
P49006 (MARCKSL1) S71 PhosphoSitePlus 18077418
P49736 (MCM2) S108 neXtProt   PhosphoSitePlus   Signor 15210935
P49917 (LIG4) S199 neXtProt 10608806
P49959 (MRE11) S264 neXtProt 10608806
P49959 (MRE11) S382 neXtProt 10608806
P49959 (MRE11) S531 neXtProt 10608806
P51587 (BRCA2) S2156 neXtProt 10608806
P54132 (BLM) T99 neXtProt   PhosphoSitePlus 14729972
P54132 (BLM) T122 neXtProt   PhosphoSitePlus 14729972
P55072 (VCP) S784 PhosphoSitePlus 18077418
P55957 (BID) S78 neXtProt 16122426
P78527 (PRKDC) T2609 PhosphoSitePlus   Signor 16908529
P78527 (PRKDC) S2612 PhosphoSitePlus 18077418
P78527 (PRKDC) T2647 PhosphoSitePlus 16908529
Q00987 (MDM2) S407 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14654783
Q01094 (E2F1) S31 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 11459832
Q01844 (EWSR1) T79 PhosphoSitePlus 19076070
Q03164 (KMT2A) S516 neXtProt   PhosphoSitePlus   Signor 20818375, 4709074
Q06190 (PPP2R3A) S61 neXtProt 10608806
Q10567 (AP1B1) S936 neXtProt 10608806
Q13098 (GPS1) S474 PhosphoSitePlus 18077418
Q13315 (ATM) S440 neXtProt 10608806
Q13315 (ATM) S1981 PhosphoSitePlus   Signor 17124492, 16293623
Q13315 (ATM) S2761 neXtProt 10608806
Q13535 (ATR) S1333 neXtProt 10608806
Q13535 (ATR) T1989 neXtProt   PhosphoSitePlus 21777809
Q13541 (EIF4EBP1) S94 neXtProt 10608806
Q14191 (WRN) S1141 neXtProt   PhosphoSitePlus 10608806, 26695548
Q14191 (WRN) S1292 neXtProt 10608806
Q14674-2 (ESPL1) S1615 neXtProt 10608806
Q14676 (MDC1) S513 PhosphoSitePlus 18077418
Q14683 (SMC1A) S957 PhosphoSitePlus 18077418
Q66K89 (E4F1) S356 neXtProt 10608806
Q6PGQ7 (BORA) T501 PhosphoSitePlus 23592782
Q7Z6Z7 (HUWE1) S2391 PhosphoSitePlus 18077418
Q8IUQ4 (SIAH1) S19 neXtProt   PhosphoSitePlus 18536714
Q8IX01 (SUGP2) T7 PhosphoSitePlus 18077418
Q8N163 (CCAR2) T454 PhosphoSitePlus   Signor 18077418, 22735644
Q8N4S0 (CCDC82) S154 PhosphoSitePlus 18077418
Q8TAQ2 (SMARCC2) S969 neXtProt   PhosphoSitePlus 19525936
Q8WVB6 (CHTF18) S74 PhosphoSitePlus 18077418
Q8WXE1 (ATRIP) S68 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15451423
Q8WXE1-1 (ATRIP) S72 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15451423
Q92878 (RAD50) S635 RLIMS-P+ 24694934
Q92888-2 (ARHGEF1) S866 neXtProt 10608806
Q96RL1 (UIMC1) S205 PhosphoSitePlus 18519686
Q96SD1 (DCLRE1C) S516 PhosphoSitePlus 19423708
Q96SD1 (DCLRE1C) S645 PhosphoSitePlus 19423708
Q99708 (RBBP8) T859 neXtProt   PhosphoSitePlus   Signor 23273981
Q9BUG6 (ZSCAN5A) T422 PhosphoSitePlus 18077418
Q9BXW9 (FANCD2) T596 PhosphoSitePlus 16943440
Q9BXW9 (FANCD2) T608 PhosphoSitePlus 16943440
Q9BXW9 (FANCD2) T691 neXtProt   PhosphoSitePlus   Signor 16943440
Q9BXW9 (FANCD2) S717 neXtProt   PhosphoSitePlus   Signor 16943440
Q9H6E5 (TUT1) S750 PhosphoSitePlus 18077418
Q9NS23-4 (RASSF1) S61 neXtProt 10608806
Q9NS23-2 (RASSF1) S131 PhosphoSitePlus 25368379
Q9NZC9 (SMARCAL1) S652 PhosphoSitePlus   Signor 23873943
Q9NZN8 (CNOT2) S101 PhosphoSitePlus 18077418
Q9UBU7 (DBF4) T449 neXtProt   PhosphoSitePlus   Signor 22123827
Q9UBU7 (DBF4) S502 neXtProt   PhosphoSitePlus   Signor 22123827
Q9UBU7 (DBF4) S539 neXtProt   PhosphoSitePlus   Signor 22123827
Q9UER7 (DAXX) S424 PhosphoSitePlus 18077418
Q9UFW8 (CGGBP1) S164 PhosphoSitePlus 24196442
Q9UH99 (SUN2) S12 PhosphoSitePlus 18077418
Q9Y248 (GINS2) S182 PhosphoSitePlus 18077418
Q9Y253 (POLH) S601 neXtProt   PhosphoSitePlus   Signor 21242293
Q9Y285 (FARSA) S301 PhosphoSitePlus 18077418


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13535 (ATR) S435 Q02952 (AKAP12) increased_association eFIP 28916831
Phosphorylation Q13535 (ATR) T1989 Q92547 (TOPBP1) unknown eFIP 29163782
Phosphorylation Q13535 (ATR) S435 P23025 (XPA) increased_association eFIP 28916831
Phosphorylation Q13535 (ATR) S435 P23025 (XPA) inhibited_association eFIP 24950377
Phosphorylation Q92547 (TOPBP1) S1159 Q13535 (ATR) inhibited_association eFIP 22481935


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S61 C61 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S61 F61 Biomuta DOID:1612 / breast cancer [ cosmic ]
S95 R95 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R177 Q177 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ icgc ]
K297 N297 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
S428 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S436 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S436 L436 Biomuta DOID:363 / uterine cancer [ icgc ]
S441 F441 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K459 N459 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S549 C549 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S549 G549 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C607 R607 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K695 E695 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K764 E764 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
K918 E918 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1140 N1140 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1173 N1173 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T1275 A1275 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1308 E1308 Biomuta DOID:1612 / breast cancer [ cosmic ]
T1566 N1566 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K1600 N1600 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1613 T1613 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1645 F1645 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C1721 F1721 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1875 N1875 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1875 R1875 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1989 P1989 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T1989 S1989 Biomuta DOID:1324 / lung cancer [ cosmic ]
K2026 M2026 Biomuta [ cosmic ]
S2075 F2075 Biomuta DOID:4159 / skin cancer [ cosmic ]
K2221 E2221 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S2313 Y2313 Biomuta DOID:363 / uterine cancer [ icgc ]
S2313 C2313 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2414 L2414 Biomuta DOID:1324 / lung cancer [ cosmic ]
K2420 N2420 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2587 N2587 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K2587 R2587 Biomuta DOID:9256 / colorectal cancer [ cosmic ]