iPTMnet Report for Q13526 (PIN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13526 / PIN1_HUMAN
Protein Name Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Gene Name Name: PIN1
Organism Homo sapiens (Human)

PRO ID PR:Q13526
DAG View
PRO Name peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (human)
Definition A peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 that is encoded in the genome of human.
Short Label hPIN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13526 (PIN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Sumoylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
S16 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor 29665256, 11723108, 23456038, ...22562304, 22261503, 20060900, 24265246, 20529865, 23970419
S16 Phosphorylation O14965 (AURKA) PhosphoSitePlus   Signor 23970419
S16 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 11723108
S16 Phosphorylation P41279 (MAP3K8) RLIMS-P+ 24265246
Y23 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S43 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
K46 Acetylation PhosphoSitePlus   UniProt 19608861
S58 Phosphorylation PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
K63 Sumoylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
S65 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16118204, 29665256
S65 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus   Signor 16118204
S71 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 26387736, 29665256, 35002518, ...21497122, 29686383, 25849135
S71 Phosphorylation P53355 (DAPK1) neXtProt   PhosphoSitePlus 26387736, 21497122
S72 Phosphorylation PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
K82 Sumoylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S108 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332
S114 Phosphorylation HPRD   PhosphoSitePlus 18452278
S115 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 25519816, 22566623
S138 Phosphorylation Q16584 (MAP3K11) PhosphoSitePlus   Signor 25519816, 22566623
R142 Methylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O60885 (BRD4) S484 Q13526 (PIN1) unknown eFIP 28481868
Phosphorylation P04637 (TP53) S46 Q13526 (PIN1) increased_association eFIP 30718466
Phosphorylation P06400 (RB1) S608 Q13526 (PIN1) unknown eFIP 22322860
Phosphorylation P14598 (NCF1) S345 Q13526 (PIN1) unknown eFIP 20956805
Phosphorylation P25205 (MCM3) T722 Q13526 (PIN1) unknown eFIP 30316783
Phosphorylation P47900 (P2RY1) S252 Q13526 (PIN1) unknown eFIP 27863418
Phosphorylation P78543 (BTG2) S147 Q13526 (PIN1) unknown eFIP 15788397
Phosphorylation Q07812 (BAX) T167 Q13526 (PIN1) unknown eFIP 19182807
Phosphorylation Q14653 (IRF3) S339 Q13526 (PIN1) unknown eFIP 16699525
Phosphorylation Q16236 (NFE2L2) S408 Q13526 (PIN1) unknown eFIP 34918396


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025637 (hCCNE1/iso:3/Phos:1) Interaction PR:Q13526 (hPIN1) PRO 16223725


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S71 L71 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S105 F105 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S108 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R142 L142 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]