iPTMnet Report for Q13505 (MTX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13505 / MTX1_HUMAN
Protein Name Metaxin-1
Gene Name Name: MTX1
Synonyms:MTX,MTXN;
Organism Homo sapiens (Human)

PRO ID PR:Q13505
DAG View
PRO Name metaxin-1 (human)
Definition A metaxin-1 that is encoded in the genome of human.
Short Label hMTX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13505 (MTX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
T14 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus   UniProt 25621951
K190 Ubiquitination PhosphoSitePlus   UniProt 25621951
S197 Phosphorylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K227 Acetylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus   UniProt 25621951
Y232 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus   UniProt 25621951
K368 Ubiquitination PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
Y415 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S12 L12 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T39 A39 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S87 P87 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K218 N218 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]