iPTMnet Report for Q13501 (SQSTM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13501 / SQSTM_HUMAN
Protein Name Sequestosome-1
Gene Name Name: SQSTM1
Synonyms:ORCA,OSIL;
Organism Homo sapiens (Human)

PRO ID PR:Q13501
DAG View
PRO Name sequestosome-1 (human)
Definition A sequestosome-1 that is encoded in the genome of human.
Short Label hSQSTM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13501 (SQSTM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K7 Ubiquitination PhosphoSitePlus
Y9 Phosphorylation PhosphoSitePlus
K13 Acetylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus   UniProt 24275569
S28 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S49 Phosphorylation PhosphoSitePlus
Y67 Phosphorylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus   UniProt 27880896
T138 Phosphorylation PhosphoSitePlus   RLIMS-P 29519959
K141 Ubiquitination PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
Y148 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15592455, 30349045
S152 Phosphorylation PhosphoSitePlus
C154 Methylation IEDB 31844290
K157 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
S170 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 20068231, ...30349045
S176 Phosphorylation PhosphoSitePlus   UniProt 24275569
S182 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R183 Methylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus   UniProt 27880896
S207 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
R209 Methylation PhosphoSitePlus
T221 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus   UniProt 24275569
S249 Phosphorylation PhosphoSitePlus   UniProt 20068231
K264 Ubiquitination PhosphoSitePlus
S266 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17081983, 20068231, 24886973
T269 Phosphorylation P06493 (CDK1) , O15264 (MAPK13) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20974803, 16083285, 17287340, ...16964243, 26279575, 18691976, 16565220, 18669648, 23186163, 24886973, 17081983
S272 Phosphorylation P06493 (CDK1) , O15264 (MAPK13) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20974803, 21406692, 16083285, ...23186163, 17081983, 26279575, 18691976, 16565220, 18669648, 24886973, 20068231, 16964243
S275 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S276 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S277 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T278 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
K281 Ubiquitination PhosphoSitePlus
S282 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S284 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S287 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S288 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S291 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S294 Phosphorylation PhosphoSitePlus
K295 Acetylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus   UniProt 24275569
K313 Ubiquitination PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
S328 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
T339 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
S343 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K344 Acetylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus   RLIMS-P 27846364, 30533198, 36165926, ...27345495, 34405859, 31586112, 32835772, 32863217, 24886973
T350 Phosphorylation PhosphoSitePlus
S355 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S361 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17287340, 19690332
S365 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17287340
S366 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 18669648, 23186163, ...24275569
S370 Phosphorylation PhosphoSitePlus
T375 Phosphorylation PhosphoSitePlus
K378 Acetylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
Y383 Phosphorylation PhosphoSitePlus
S403 Phosphorylation Q9UHD2 (TBK1) PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 25040165, 32131874, 27846364, ...27631370, 28159418, 29496741, 33077977, 25972374, 29941919, 22017874, 22921120, 33044112, 24886973, 34226595, 32835772
S407 Phosphorylation PhosphoSitePlus   RLIMS-P 27846364
K420 Acetylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus   UniProt 28380357
T430 Phosphorylation PhosphoSitePlus
Y433 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
K435 Acetylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation HPRD 20068231
S28 Phosphorylation HPRD 18669648, 17081983
Y89 Phosphorylation HPRD 17081983, 20068231
S170 Phosphorylation HPRD 19651622, 18669648, 19007248, ...20068231
S176 Phosphorylation HPRD 20068231, 17924679
S180 Phosphorylation HPRD 17081983, 20068231
S182 Phosphorylation HPRD 18669648, 17081983
S207 Phosphorylation HPRD 18669648, 20068231
S226 Phosphorylation HPRD 20068231
S249 Phosphorylation HPRD 20068231
S266 Phosphorylation HPRD 18691976, 17081983, 19007248, ...19664995, 19651622, 20166139, 20068231
T269 Phosphorylation HPRD 19413330, 18691976, 16083285, ...17287340, 16964243, 19664994, 19664995, 16565220, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231
S272 Phosphorylation HPRD 19413330, 18691976, 18578522, ...18491316, 16964243, 18767875, 19664994, 19007248, 16565220, 19651622, 18669648, 19664995, 18707149, 19415658, 20068231, 19691289
S275 Phosphorylation HPRD 18578522, 16964243, 19664995, ...19651622, 18669648, 20068231, 17081983
S276 Phosphorylation HPRD 18669648, 17081983, 20068231
S277 Phosphorylation HPRD 19413330, 18669648, 17081983
T278 Phosphorylation HPRD 18669648, 17081983, 20068231
S282 Phosphorylation HPRD 18669648, 17081983, 20068231
S283 Phosphorylation HPRD 17081983
S284 Phosphorylation HPRD 18669648, 17081983
S287 Phosphorylation HPRD 18669648
S288 Phosphorylation HPRD 18669648
S291 Phosphorylation HPRD 18669648
S318 Phosphorylation HPRD 17081983, 20068231
S328 Phosphorylation HPRD 18669648, 17081983, 20068231
S332 Phosphorylation HPRD 18669648, 17081983, 20068231
T339 Phosphorylation HPRD 17081983
S342 Phosphorylation HPRD 17081983
S343 Phosphorylation HPRD 18669648, 17081983
S355 Phosphorylation HPRD 18669648
S361 Phosphorylation HPRD 18669648, 17287340, 20068231
S365 Phosphorylation HPRD 18691976, 18669648, 17287340, ...17081983, 20068231
S366 Phosphorylation HPRD 19413330, 17287340, 17081983, ...19664995, 19007248, 18669648, 19415658, 20068231
S370 Phosphorylation HPRD 19413330, 17081983
T375 Phosphorylation HPRD 17081983


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13501 (SQSTM1) S349 Q14145 (KEAP1) increased_association eFIP 33854041


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T138 I138 Biomuta DOID:3571 / liver cancer [ cosmic ]
S143 C143 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S152 C152 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K157 Q157 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K165 R165 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S180 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R183 P183 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R183 C183 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R183 H183 Biomuta DOID:363 / uterine cancer [ icgc ]
R209 H209 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T221 M221 Biomuta DOID:184 / bone cancer [ cosmic ]
S226 F226 Biomuta DOID:1324 / lung cancer [ cosmic ]
S266 R266 Biomuta DOID:363 / uterine cancer [ icgc ]
S276 Y276 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S277 I277 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S277 G277 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S284 L284 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S284 A284 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S318 Y318 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S328 L328 Biomuta DOID:363 / uterine cancer [ icgc ]
T350 I350 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S365 N365 Biomuta DOID:4159 / skin cancer [ cosmic ]
S403 F403 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K420 N420 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]