Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13485 / SMAD4_HUMAN
Protein Name Mothers against decapentaplegic homolog 4
Gene Name Name: SMAD4
Synonyms:DPC4,MADH4;
Organism Homo sapiens (Human)

PRO ID PR:Q13485
DAG View
PRO Name mothers against decapentaplegic homolog 4 (human)
Definition A smad4 that is encoded in the genome of human.
Short Label hSMAD4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13485 (SMAD4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation Q9UBE8 (NLK) neXtProt   PhosphoSitePlus   RLIMS-P 19690946
S22 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
K37 Acetylation PhosphoSitePlus   UniProt 19608861
K45 Acetylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K48 Acetylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
T77 Phosphorylation Q15831 (STK11) neXtProt   PhosphoSitePlus   RLIMS-P 20974850
Y95 Phosphorylation PhosphoSitePlus   RLIMS-P 30664791
K106 Acetylation PhosphoSitePlus
K113 Sumoylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S138 Phosphorylation Q9UBE8 (NLK) neXtProt   PhosphoSitePlus   RLIMS-P 19690946
K159 Sumoylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
T273 Phosphorylation PhosphoSitePlus
T277 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 27308538, 28115363, 12801888
S343 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus 20659902
K385 Ubiquitination PhosphoSitePlus
K428 Acetylation PhosphoSitePlus   UniProt 19608861
S504 Phosphorylation PhosphoSitePlus
K507 Acetylation PhosphoSitePlus   UniProt 19608861
K507 Ubiquitination PhosphoSitePlus
Y513 Phosphorylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus   UniProt 19135894
Site PTM Type PTM Enzyme Score Source PMID
T277 Phosphorylation PRO 12801888
K507 Ubiquitination PRO 18783722
K519 Ubiquitination PRO 19135894


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025956 (hSMAD4/iso:1/MonoUbiq:1) ubK507 PRO 18783722
PR:000025958 (hSMAD4/iso:1/MonoUbiq:2) ubK519 PRO 19135894
PR:000036483 (hSMAD4/iso:1/Phos:1) pT277 PRO 12801888


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P84022 (SMAD3) T388 Q13485 (SMAD4) increased_association eFIP 24485922
Phosphorylation Q15796 (SMAD2) S465 Q13485 (SMAD4) unknown eFIP 9346908
Phosphorylation Q15796 (SMAD2) S465 Q13485 (SMAD4) unknown eFIP 9346966


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025934 (hSMAD2/iso:Long/Phos:1) Interaction PR:Q13485 (hSMAD4) PRO 9311995
PR:000025935 (hSMAD2/iso:Long/Phos:2) Interaction PR:Q13485 (hSMAD4) PRO 12193595
PR:000025936 (hSMAD2/iso:Long/Phos:3) Interaction PR:Q13485 (hSMAD4) PRO 11027280
PR:000026333 (hSMAD3/iso:1/Phos:1) Interaction PR:Q13485 (hSMAD4) PRO 15350224, 9311995
PR:000026334 (hSMAD1/iso:1/Phos:1) Interaction PR:Q13485 (hSMAD4) PRO 9136927


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S32 T32 Biomuta DOID:4362 / cervical cancer [ icgc, tcga ]
K70 T70 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K70 * Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y95 S95 Biomuta DOID:0070003 / blastoma [ cosmic ]
Y95 C95 Biomuta DOID:1324 / lung cancer [ tcga ] DOID:263 / kidney cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
K106 R106 Biomuta DOID:1324 / lung cancer [ cosmic ]
S138 L138 Biomuta DOID:1909 / melanoma [ cosmic ]
S138 * Biomuta DOID:1909 / melanoma [ cosmic ] DOID:0070003 / blastoma [ cosmic ]
S178 * Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S343 * Biomuta DOID:0070003 / blastoma [ cosmic ]
S343 L343 Biomuta DOID:1909 / melanoma [ cosmic ]
K428 T428 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
K428 N428 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, tcga ] DOID:0070003 / blastoma [ cosmic ]
K428 M428 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S504 R504 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10534 / stomach cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
K507 N507 Biomuta DOID:10534 / stomach cancer [ tcga ]
Y513 * Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K519 N519 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K519 * Biomuta DOID:1324 / lung cancer [ tcga ]