iPTMnet Report for Q13472 (TOP3A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13472 / TOP3A_HUMAN
Protein Name DNA topoisomerase 3-alpha
Gene Name Name: TOP3A
Synonyms:TOP3;
Organism Homo sapiens (Human)

PRO ID PR:Q13472
DAG View
PRO Name DNA topoisomerase 3-alpha (human)
Definition A DNA topoisomerase 3-alpha that is encoded in the genome of human.
Short Label hTOP3A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13472 (TOP3A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
S54 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K66 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
C296 Methylation IEDB 31844290
K321 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
T554 Phosphorylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
K668 Acetylation PhosphoSitePlus
T669 Phosphorylation PhosphoSitePlus
K670 Acetylation PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus
S771 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S778 Phosphorylation PhosphoSitePlus
S964 Phosphorylation PhosphoSitePlus
S970 Phosphorylation PhosphoSitePlus
S971 Phosphorylation PhosphoSitePlus
S972 Phosphorylation PhosphoSitePlus
S976 Phosphorylation PhosphoSitePlus
T977 Phosphorylation PhosphoSitePlus
S985 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S54 Phosphorylation HPRD 18669648
T669 Phosphorylation HPRD 20166139
S771 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K47 N47 Biomuta [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
C296 Y296 Biomuta DOID:1612 / breast cancer [ cosmic ]
K529 N529 Biomuta DOID:1324 / lung cancer [ cosmic ]
K557 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K668 R668 Biomuta DOID:184 / bone cancer [ cosmic ]
S694 L694 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]