Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13469 / NFAC2_HUMAN
Protein Name Nuclear factor of activated T-cells, cytoplasmic 2
Gene Name Name: NFATC2
Synonyms:NFAT1,NFATP;
Organism Homo sapiens (Human)

PRO ID PR:Q13469
DAG View
PRO Name nuclear factor of activated T-cells, cytoplasmic 2 (human)
Definition A nuclear factor of activated T-cells, cytoplasmic 2 that is encoded in the genome of human.
Short Label hNFATC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13469 (NFATC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation PhosphoSitePlus   UniProt 24275569
S31 Phosphorylation Q86Y07 (VRK2) Signor 23105117
Y36 Phosphorylation PhosphoSitePlus
Y38 Phosphorylation PhosphoSitePlus
S53 Phosphorylation Q05513 (PRKCZ) neXtProt   PhosphoSitePlus   RLIMS-P 17398070, 12021260
S56 Phosphorylation Q05513 (PRKCZ) neXtProt   RLIMS-P 12021260, 17398070
K70 Ubiquitination PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus   RLIMS-P 29357353
K96 Ubiquitination PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus   UniProt 23186163
S110 Phosphorylation PhosphoSitePlus   UniProt 23186163
T116 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus   UniProt 19690332, 24275569
R150 Methylation PhosphoSitePlus
S171 Phosphorylation PRO
S172 Phosphorylation PRO
S174 Phosphorylation PRO
S175 Phosphorylation PRO
S177 Phosphorylation PRO   RLIMS-P 27863227
Y212 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PRO   PhosphoSitePlus
S217 Phosphorylation PRO   PhosphoSitePlus
S221 Phosphorylation PRO   PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PRO   PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PRO   PhosphoSitePlus
S274 Phosphorylation PRO
S276 Phosphorylation PRO
S280 Phosphorylation PRO
T325 Phosphorylation PhosphoSitePlus
S326 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   UniProt 23186163, 15144186
S330 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 15144186
S333 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
Y346 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
T374 Phosphorylation PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
T483 Phosphorylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
T585 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T599 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S605 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T652 Phosphorylation PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
S737 Phosphorylation PhosphoSitePlus
Y752 Phosphorylation PhosphoSitePlus
S755 Phosphorylation PhosphoSitePlus   UniProt 19690332
S757 Phosphorylation PhosphoSitePlus   UniProt 20068231
S759 Phosphorylation PhosphoSitePlus   UniProt 19690332, 20068231
S761 Phosphorylation PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
S801 Phosphorylation PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
S814 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus   UniProt 23186163
S859 Phosphorylation PhosphoSitePlus   UniProt 19690332
Y860 Phosphorylation PhosphoSitePlus
S882 Phosphorylation PhosphoSitePlus
K885 Ubiquitination PhosphoSitePlus
T893 Phosphorylation PhosphoSitePlus
K895 Sumoylation PhosphoSitePlus
Y904 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S77 Phosphorylation HPRD 20068231
S99 Phosphorylation HPRD 11030334
S168 Phosphorylation HPRD 11030334
S171 Phosphorylation HPRD 11030334
S172 Phosphorylation HPRD 11030334
S174 Phosphorylation HPRD 11030334
S175 Phosphorylation HPRD 11030334
S177 Phosphorylation HPRD 11030334
S180 Phosphorylation HPRD 11030334
S213 Phosphorylation HPRD 11030334
S217 Phosphorylation HPRD 11030334
S221 Phosphorylation HPRD 11030334
S236 Phosphorylation HPRD 11030334
S243 Phosphorylation HPRD 11030334
S268 Phosphorylation HPRD 11030334
S274 Phosphorylation HPRD 11030334
S276 Phosphorylation HPRD 11030334
S280 Phosphorylation HPRD 11030334
T325 Phosphorylation HPRD 20068231
S326 Phosphorylation HPRD 11030334, 15144186, 20068231
S330 Phosphorylation HPRD 15144186, 20068231
S363 Phosphorylation HPRD 19651622, 11030334
T374 Phosphorylation HPRD 20068231
T483 Phosphorylation HPRD 20068231
T585 Phosphorylation HPRD 17287340
T599 Phosphorylation HPRD 17287340
S605 Phosphorylation HPRD 17287340
S757 Phosphorylation HPRD 20068231
S759 Phosphorylation HPRD 20068231
S882 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S77 Phosphorylation HPRD 20068231
S99 Phosphorylation HPRD 11030334
S168 Phosphorylation HPRD 11030334
S171 Phosphorylation HPRD 11030334
S172 Phosphorylation HPRD 11030334
S174 Phosphorylation HPRD 11030334
S175 Phosphorylation HPRD 11030334
S180 Phosphorylation HPRD 11030334
S213 Phosphorylation HPRD 11030334
S217 Phosphorylation HPRD 11030334
S221 Phosphorylation HPRD 11030334
S236 Phosphorylation HPRD 11030334
S243 Phosphorylation HPRD 11030334
S268 Phosphorylation HPRD 11030334
S274 Phosphorylation HPRD 11030334
S276 Phosphorylation HPRD 11030334
S280 Phosphorylation HPRD 11030334
T325 Phosphorylation HPRD 20068231
S326 Phosphorylation HPRD 11030334, 15144186, 20068231
S330 Phosphorylation HPRD 15144186, 20068231
S363 Phosphorylation HPRD 19651622, 11030334
T374 Phosphorylation HPRD 20068231
T483 Phosphorylation HPRD 20068231
T585 Phosphorylation HPRD 17287340
T599 Phosphorylation HPRD 17287340
S605 Phosphorylation HPRD 17287340
S757 Phosphorylation HPRD 20068231
S759 Phosphorylation HPRD 20068231
S882 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048590 (hNFATC2/Phos:1) pS171,pS172,pS174,pS175,pS177,pS213,pS217,pS221,pS243,pS268,pS274,pS276,pS280,pS326 PRO
PR:000048591 (hNFATC2/Phos:2) pS243 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S53 N53 Biomuta DOID:363 / uterine cancer [ tcga ]
S56 F56 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S73 R73 Biomuta DOID:3571 / liver cancer [ icgc ]
S77 G77 Biomuta DOID:10534 / stomach cancer [ tcga ]
S77 N77 Biomuta DOID:363 / uterine cancer [ tcga ]
K96 N96 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S107 L107 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
S172 N172 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S175 F175 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S221 L221 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S221 * Biomuta DOID:3571 / liver cancer [ icgc ]
S230 I230 Biomuta DOID:363 / uterine cancer [ tcga ]
S255 L255 Biomuta DOID:1909 / melanoma [ tcga ] DOID:3070 / malignant glioma [ tcga ]
S276 L276 Biomuta DOID:1612 / breast cancer [ tcga ]
S280 L280 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T325 N325 Biomuta DOID:3571 / liver cancer [ icgc ]
S326 I326 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S326 N326 Biomuta DOID:363 / uterine cancer [ cosmic ]
S333 F333 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y346 * Biomuta DOID:3571 / liver cancer [ icgc ]
K497 E497 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K520 N520 Biomuta DOID:363 / uterine cancer [ tcga ]
S737 P737 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:3070 / malignant glioma [ tcga ]
S759 R759 Biomuta DOID:3571 / liver cancer [ icgc ]
S808 L808 Biomuta DOID:5041 / esophageal cancer [ tcga ] DOID:1324 / lung cancer [ cosmic, icgc, tcga ] DOID:2531 / hematologic cancer [ tcga ] DOID:11934 / head and neck cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
Y860 C860 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T893 A893 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]