iPTMnet Report for Q13451 (FKBP5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13451 / FKBP5_HUMAN
Protein Name Peptidyl-prolyl cis-trans isomerase FKBP5
Gene Name Name: FKBP5
Synonyms:AIG6,FKBP51;
Organism Homo sapiens (Human)

PRO ID PR:Q13451
DAG View
PRO Name peptidyl-prolyl cis-trans isomerase FKBP5 (human)
Definition A peptidyl-prolyl cis-trans isomerase FKBP5 that is encoded in the genome of human.
Short Label hFKBP5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13451 (FKBP5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
S13 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163
T15 Phosphorylation PhosphoSitePlus
K28 Acetylation PhosphoSitePlus   UniProt 28147277
K28 Ubiquitination PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
K66 Acetylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus   UniProt 28147277
K208 Ubiquitination PhosphoSitePlus
C215 Methylation IEDB 31844290
Y243 Phosphorylation PhosphoSitePlus
K248 Acetylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
R357 Methylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
Y409 Phosphorylation PhosphoSitePlus
K414 Acetylation PhosphoSitePlus
K415 Acetylation PhosphoSitePlus
K422 Sumoylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
T433 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
K441 Acetylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
T443 Phosphorylation PhosphoSitePlus
S445 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 18669648
Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation HPRD 15302935, 20068231
S445 Phosphorylation HPRD 17525332, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y54 H54 Biomuta DOID:4159 / skin cancer [ cosmic ]
C215 S215 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y243 C243 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R357 M357 Biomuta DOID:363 / uterine cancer [ icgc ]