Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13435 / SF3B2_HUMAN
Protein Name Splicing factor 3B subunit 2
Gene Name Name: SF3B2
Synonyms:SAP145;
Organism Homo sapiens (Human)

PRO ID PR:Q13435
DAG View
PRO Name splicing factor 3B subunit 2 (human)
Definition A splicing factor 3B subunit 2 that is encoded in the genome of human.
Short Label hSF3B2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13435 (SF3B2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R71 Methylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
R192 Methylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
T201 Phosphorylation HPRD   PhosphoSitePlus 18669648
R205 Methylation PhosphoSitePlus
R216 Methylation PhosphoSitePlus
T217 Phosphorylation HPRD   PhosphoSitePlus 18669648
R222 Methylation PhosphoSitePlus   UniProt 24129315
R245 Methylation PhosphoSitePlus   UniProt 24129315
R247 Methylation PhosphoSitePlus   UniProt 24129315
R258 Methylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
K268 Methylation PhosphoSitePlus
K275 Acetylation PhosphoSitePlus   UniProt 19608861
K275 Ubiquitination PhosphoSitePlus
K280 Sumoylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S289 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 23186163, 29705135, ...18452278, 18669648
T298 Phosphorylation PhosphoSitePlus   UniProt 23186163
S302 Phosphorylation HPRD   PhosphoSitePlus 17081983, 18452278, 19651622, ...18669648, 20068231
S303 Phosphorylation HPRD   PhosphoSitePlus 18669648, 18452278, 19664995, ...17081983
S307 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 18691976, ...19664994, 15302935, 19664995, 18452278, 19651622, 18669648, 19690332, 19415658, 20068231
S309 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 18691976, ...15302935, 19664994, 19664995, 18452278, 19651622, 18669648, 19415658, 19690332, 20068231
T311 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 17081983, 18452278, ...19651622, 18669648, 24275569, 19415658, 20068231
T315 Phosphorylation HPRD   PhosphoSitePlus 20068231
S317 Phosphorylation PhosphoSitePlus   UniProt 23186163
R340 Methylation PhosphoSitePlus
S343 Phosphorylation HPRD   PhosphoSitePlus 17287340, 20068231
S344 Phosphorylation HPRD   PhosphoSitePlus 20068231
S346 Phosphorylation HPRD   PhosphoSitePlus 20068231
S347 Phosphorylation HPRD   PhosphoSitePlus 20068231
K352 Ubiquitination PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
S360 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17287340, 19690332, 18452278
S362 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18452278, 19690332, 20068231, ...17081983
Y371 Phosphorylation HPRD   PhosphoSitePlus 18452278
T373 Phosphorylation HPRD   PhosphoSitePlus 17081983
Y379 Phosphorylation P12931 (SRC) PhosphoSitePlus 18698806
K394 Ubiquitination PhosphoSitePlus
K400 Sumoylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
K412 Acetylation PhosphoSitePlus
K412 Sumoylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
S416 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S431 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...18452278, 19651622, 18669648, 24275569, 20166139, 23186163, 18318008, 19415658, 20068231
S435 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18318008, 19651622, 18669648, 24275569, 20166139, 17287340, 18452278, 19415658, 20068231
S436 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18318008, 19651622, 18669648, 24275569, 20166139, 17287340, 18452278, 19415658, 20068231
S450 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K492 Methylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
R502 Methylation PhosphoSitePlus
K507 Methylation PhosphoSitePlus
R508 Methylation PhosphoSitePlus   UniProt 25737013
R515 Methylation PhosphoSitePlus   UniProt 24129315
K519 Ubiquitination PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
R537 Methylation PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
T548 Phosphorylation PhosphoSitePlus
K563 Ubiquitination PhosphoSitePlus
Y568 Phosphorylation PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
K577 Acetylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
Y591 Phosphorylation PhosphoSitePlus
Y592 Phosphorylation P12931 (SRC) PhosphoSitePlus 18698806
K605 Sumoylation PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
R614 Methylation PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
S655 Phosphorylation PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
K680 Sumoylation PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
K697 Sumoylation PhosphoSitePlus
T698 Phosphorylation HPRD   PhosphoSitePlus 20068231
T739 Phosphorylation HPRD 20068231
S743 Phosphorylation HPRD 20068231
S752 Phosphorylation HPRD 20068231
T760 Phosphorylation HPRD   PhosphoSitePlus 20068231
K770 Sumoylation PhosphoSitePlus
S778 Phosphorylation HPRD   PhosphoSitePlus 17287340, 17081983, 19664995, ...18669648, 20068231
T780 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 17287340, 17081983, ...19664995, 18452278, 19651622, 18669648, 23186163, 19690332, 20068231
T785 Phosphorylation PhosphoSitePlus
K790 Ubiquitination PhosphoSitePlus
T794 Phosphorylation HPRD 20068231
S802 Phosphorylation HPRD 20068231
T803 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y806 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S809 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
T810 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S813 Phosphorylation HPRD   PhosphoSitePlus 20068231
K843 Methylation PhosphoSitePlus
K843 Ubiquitination PhosphoSitePlus
Y844 Phosphorylation PhosphoSitePlus
S861 Phosphorylation PhosphoSitePlus   UniProt 23186163
K870 Ubiquitination PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
R884 Methylation PhosphoSitePlus
S887 Phosphorylation PhosphoSitePlus
K888 Acetylation PhosphoSitePlus
K889 Acetylation PhosphoSitePlus
Y890 Phosphorylation PhosphoSitePlus
K891 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K182 E182 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R205 W205 Biomuta DOID:11054 / urinary bladder cancer [ icgc, tcga ]
R245 W245 Biomuta DOID:1324 / lung cancer [ cosmic ]
R245 Q245 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S264 F264 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S289 C289 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S307 L307 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S346 I346 Biomuta DOID:3571 / liver cancer [ icgc ]
S347 F347 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
Y371 C371 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T373 S373 Biomuta DOID:3070 / malignant glioma [ tcga ]
K492 N492 Biomuta DOID:3571 / liver cancer [ icgc ]
R502 H502 Biomuta DOID:4362 / cervical cancer [ tcga ]
R502 L502 Biomuta DOID:3571 / liver cancer [ icgc ]
R508 H508 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ tcga ]
K577 R577 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K627 N627 Biomuta DOID:3571 / liver cancer [ icgc ]
K672 R672 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K697 N697 Biomuta DOID:363 / uterine cancer [ tcga ]
K790 N790 Biomuta DOID:1612 / breast cancer [ cosmic ]
S802 L802 Biomuta DOID:1324 / lung cancer [ cosmic ]
T810 M810 Biomuta DOID:10534 / stomach cancer [ cosmic, tcga ] DOID:1324 / lung cancer [ icgc, tcga ]
S883 R883 Biomuta DOID:363 / uterine cancer [ tcga ]
K888 T888 Biomuta DOID:363 / uterine cancer [ tcga ]
K888 N888 Biomuta DOID:1909 / melanoma [ cosmic ]