iPTMnet Report for Q13426 (XRCC4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13426 / XRCC4_HUMAN
Protein Name DNA repair protein XRCC4
Gene Name Name: XRCC4
Organism Homo sapiens (Human)

PRO ID PR:Q13426
DAG View
PRO Name DNA repair protein XRCC4 (human)
Definition A DNA repair protein XRCC4 that is encoded in the genome of human.
Short Label hXRCC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13426 (XRCC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
T17 Phosphorylation PhosphoSitePlus
S53 Phosphorylation UniProt 14599745
K65 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
C128 Methylation IEDB 31844290
K146 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S193 Phosphorylation phospho.ELM   UniProt 14599745, 22228831, 28500754
K197 Ubiquitination PhosphoSitePlus
K210 Sumoylation PRO   PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
Y229 Phosphorylation PhosphoSitePlus   UniProt 24275569
S232 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28453785, 29059378
T233 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P   UniProt 28453785, 20852255, 29059378, ...15385968, 18077224, 24275569
S237 Phosphorylation PhosphoSitePlus   UniProt 24275569
T241 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus   UniProt 20068231
S259 Phosphorylation PhosphoSitePlus
S260 Phosphorylation P78527 (PRKDC) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 22228831, 15177042, ...30247612, 28500754, 14599745, 12218164, 26666690
T264 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus   UniProt 26774286
S299 Phosphorylation PhosphoSitePlus
S303 Phosphorylation UniProt 22228831, 14599745
S304 Phosphorylation P78527 (PRKDC) phospho.ELM   PhosphoSitePlus   UniProt 14599745, 23186163, 28500754
S315 Phosphorylation phospho.ELM   UniProt 14599745, 22228831, 28500754
S320 Phosphorylation P78527 (PRKDC) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 22228831, 15177042, ...18669648, 28500754, 14599745, 26666690
T323 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14599745, 18669648, 22228831, ...28500754
S327 Phosphorylation P78527 (PRKDC) phospho.ELM   PhosphoSitePlus   UniProt 17081983, 22228831, 18669648, ...26774286, 28500754, 14599745, 19690332
S328 Phosphorylation P78527 (PRKDC) phospho.ELM   PhosphoSitePlus   UniProt 17081983, 22228831, 26774286, ...18669648, 28500754, 14599745, 19690332
Site PTM Type PTM Enzyme Score Source PMID
S256 Phosphorylation HPRD 20068231
S315 Phosphorylation HPRD 17081983, 20068231
S320 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
T323 Phosphorylation HPRD 18669648
S327 Phosphorylation HPRD 18669648, 20068231
S328 Phosphorylation HPRD 18669648, 17081983, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S256 Phosphorylation HPRD 20068231
S313 Phosphorylation HPRD 17081983, 20068231
S318 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
T321 Phosphorylation HPRD 18669648
S325 Phosphorylation HPRD 18669648, 20068231
S326 Phosphorylation HPRD 18669648, 17081983, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049712 (hXRCC4/Sumo:1) suK210 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 G6 Biomuta DOID:1319 / brain cancer [ icgc ]
S6 R6 Biomuta DOID:363 / uterine cancer [ icgc ]
S53 F53 Biomuta DOID:4159 / skin cancer [ cosmic ]
K146 N146 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S260 N260 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S303 Y303 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S303 F303 Biomuta DOID:4159 / skin cancer [ cosmic ]