iPTMnet Report for Q13422 (IKZF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13422 / IKZF1_HUMAN
Protein Name DNA-binding protein Ikaros
Gene Name Name: IKZF1
Synonyms:IK1,IKAROS,LYF1,ZNFN1A1;
Organism Homo sapiens (Human)

PRO ID PR:Q13422
DAG View
PRO Name DNA-binding protein Ikaros (human)
Definition A DNA-binding protein Ikaros that is encoded in the genome of human.
Short Label hIKZF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13422 (IKZF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation P67870 (CSNK2B) , P68400 (CSNK2A1) Signor 21750978
T23 Phosphorylation P68400 (CSNK2A1) , P67870 (CSNK2B) Signor 21750978
K58 Sumoylation PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
S63 Phosphorylation P68400 (CSNK2A1) , P67870 (CSNK2B) PhosphoSitePlus   Signor   UniProt 21750978, 23186163, 19690332
R83 Methylation PhosphoSitePlus
S88 O-Glycosylation GlyGen 29351928
S88 Phosphorylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S101 Phosphorylation P67870 (CSNK2B) , P68400 (CSNK2A1) Signor 21750978
S105 Phosphorylation PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
T140 Phosphorylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
K171 Acetylation PhosphoSitePlus
K171 Sumoylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
S214 Phosphorylation Q06187 (BTK) PhosphoSitePlus 23977012
S215 Phosphorylation Q06187 (BTK) PhosphoSitePlus 23977012
K220 Ubiquitination PhosphoSitePlus
K241 Sumoylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
C254 Methylation IEDB 31844290
K255 Ubiquitination PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus   UniProt 19690332
S261 Phosphorylation PhosphoSitePlus   UniProt 23186163
S269 Phosphorylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus   UniProt 23186163
T291 Phosphorylation PhosphoSitePlus
Y293 Phosphorylation PhosphoSitePlus
S295 Phosphorylation P68400 (CSNK2A1) , P67870 (CSNK2B) PhosphoSitePlus   Signor 21750978
S296 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y299 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
Y348 Phosphorylation PhosphoSitePlus
T358 Phosphorylation PhosphoSitePlus
S361 O-Glycosylation GlyGen 29351928
S361 Phosphorylation P43405 (SYK) PhosphoSitePlus   Signor   UniProt 23071339, 19690332
S364 Phosphorylation P43405 (SYK) PhosphoSitePlus   Signor   UniProt 23071339, 23186163, 19690332
S368 O-Glycosylation GlyGen 29351928
S368 Phosphorylation PhosphoSitePlus   UniProt 23186163
S377 Phosphorylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus   RLIMS-P 27026320, 32807499
S393 Phosphorylation PhosphoSitePlus   RLIMS-P 27026320
S397 Phosphorylation PhosphoSitePlus
T398 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
Y413 Phosphorylation PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus   UniProt 23186163
K429 Sumoylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
Y435 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K460 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S196 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S13 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S13 T13 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R83 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
R83 Q83 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
R83 L83 Biomuta DOID:1324 / lung cancer [ cosmic ]
S88 L88 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S101 N101 Biomuta DOID:1319 / brain cancer [ cosmic ]
S105 L105 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S168 F168 Biomuta [ cosmic ]
S168 Y168 Biomuta DOID:1324 / lung cancer [ cosmic ]
K174 E174 Biomuta DOID:363 / uterine cancer [ cosmic ]
S196 F196 Biomuta DOID:4159 / skin cancer [ cosmic ]
S214 I214 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S215 F215 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
K241 R241 Biomuta DOID:1324 / lung cancer [ cosmic ]
K255 E255 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K255 N255 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S261 Y261 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S269 G269 Biomuta DOID:4159 / skin cancer [ cosmic ]
K273 N273 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S289 Y289 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T291 R291 Biomuta DOID:363 / uterine cancer [ cosmic ]
T291 M291 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S295 G295 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S298 T298 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T333 M333 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S345 I345 Biomuta DOID:1612 / breast cancer [ cosmic ]
T358 A358 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S361 Y361 Biomuta DOID:1324 / lung cancer [ cosmic ]
S364 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K380 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K380 T380 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S393 R393 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S397 F397 Biomuta [ cosmic ]
S402 G402 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S402 R402 Biomuta DOID:363 / uterine cancer [ cosmic ]
T415 N415 Biomuta DOID:263 / kidney cancer [ cosmic ]
S427 L427 Biomuta [ cosmic ] DOID:3119 / gastrointestinal system cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]