iPTMnet Report for Q13421 (MSLN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13421 / MSLN_HUMAN
Protein Name Mesothelin precursor
Gene Name Name: MSLN
Synonyms:MPF;
Organism Homo sapiens (Human)

PRO ID PR:Q13421
DAG View
PRO Name mesothelin (human)
Definition A mesothelin that is encoded in the genome of human.
Short Label hMSLN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13421 (MSLN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K92 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus   UniProt 26091039
S262 Phosphorylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
N388 N-Glycosylation GlyGen 23090970, 29391424, 24190977
K487 Ubiquitination PhosphoSitePlus
N496 N-Glycosylation GlyGen 29741879, 29671580, 29391424
N523 N-Glycosylation GlyGen 29391424
T530 Phosphorylation PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S178 Phosphorylation HPRD 20068231
N496 N-Glycosylation PRO 29671580
T530 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S178 Phosphorylation HPRD 20068231
T522 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K95 T95 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S200 L200 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S262 I262 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K319 N319 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K353 T353 Biomuta DOID:10534 / stomach cancer [ cosmic ]