iPTMnet Report for Q13418 (ILK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13418 / ILK_HUMAN
Protein Name Integrin-linked protein kinase
Gene Name Name: ILK
Synonyms:ILK1;
Organism Homo sapiens (Human)

PRO ID PR:Q13418
DAG View
PRO Name integrin-linked protein kinase (human)
Definition An integrin-linked protein kinase that is encoded in the genome of human.
Short Label hILK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13418 (ILK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 22223895
T69 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
C129 Methylation IEDB 31844290
K139 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K170 Methylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
T173 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 27391337, 17420447, 27926483, ...27982018, 22521536, 27824126
T173 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 22521536
T173 Phosphorylation Q13153 (PAK1) neXtProt   PhosphoSitePlus   Signor 17420447
T181 Phosphorylation PhosphoSitePlus 22521536
T181 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 22521536
K184 Ubiquitination PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus   UniProt 21406692
K191 Sumoylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S246 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 32439895, 27982018, 17420447, ...32260415
S246 Phosphorylation Q13153 (PAK1) neXtProt   PhosphoSitePlus   Signor 17420447
K341 Ubiquitination PhosphoSitePlus
S343 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 11313365
S343 Phosphorylation Q13418 (ILK) phospho.ELM   Signor 11313365
C346 S-Nitrosylation dbSNO 26338901
K423 Ubiquitination PhosphoSitePlus
K426 Acetylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S343 Phosphorylation HPRD 11313365
S343 Phosphorylation Q13418 (ILK) HPRD 11313365


Q13418 (ILK) as PTM Enzyme



Substrate Site Score Source PMID
E9PAV3 (NACA) S1906 PhosphoSitePlus   Signor 15299025
O14950 (MYL12B) T19 PhosphoSitePlus   Signor 11278951
O14950 (MYL12B) S20 PhosphoSitePlus   Signor 11278951, 16472257
O14974-1 (PPP1R12A) T696 HPRD   Signor 18212344, 18767875, 11931630, ...12030846, 12600888, 12220642, 18669648, 10601309, 18077418
O14974 (PPP1R12A) T710 Signor 12030846
P23528 (CFL1) S3 Signor 18252715
P31749 (AKT1) S473 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 12642872, 11313365, 9736715, ...23840605, 12686550, 10637513
Q13418 (ILK) S343 HPRD   phospho.ELM   Signor 11313365
Q13765 (NACA) S43 phospho.ELM   Signor 15299025
Q8TAE6 (PPP1R14C) T73 phospho.ELM   PhosphoSitePlus   Signor 12804574
Q96A00 (PPP1R14A) T38 phospho.ELM   PhosphoSitePlus   Signor 12030846, 12144526
Q96C90 (PPP1R14B) T57 phospho.ELM   PhosphoSitePlus 12030846, 16397254, 12144526


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T69 I69 Biomuta [ cosmic ]
K154 N154 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T173 A173 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S186 F186 Biomuta DOID:1612 / breast cancer [ cosmic ]
S204 F204 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S204 A204 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K220 N220 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S246 L246 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]
K341 Q341 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K341 T341 Biomuta DOID:4159 / skin cancer [ cosmic ]