iPTMnet Report for Q13415 (ORC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13415 / ORC1_HUMAN
Protein Name Origin recognition complex subunit 1
Gene Name Name: ORC1
Synonyms:ORC1L,PARC1;
Organism Homo sapiens (Human)

PRO ID PR:Q13415
DAG View
PRO Name origin recognition complex subunit 1 (human)
Definition An origin recognition complex subunit 1 that is encoded in the genome of human.
Short Label hORC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13415 (ORC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K25 Sumoylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
S196 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S199 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S201 Phosphorylation PhosphoSitePlus
T203 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K210 Ubiquitination PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
T226 Phosphorylation HPRD   PhosphoSitePlus 20068231
T230 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S258 Phosphorylation P06493 (CDK1) , P24941 (CDK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11931757, 20068231
S269 Phosphorylation PhosphoSitePlus
S273 Phosphorylation P06493 (CDK1) , P24941 (CDK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19413330, 21406692, 23186163, ...11931757, 20068231
S275 Phosphorylation PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
S287 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 20068231
S311 Phosphorylation PhosphoSitePlus
K326 Acetylation PhosphoSitePlus   UniProt 19608861
T337 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S340 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S350 Phosphorylation PhosphoSitePlus
K364 Acetylation PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
T375 Phosphorylation P24941 (CDK2) , P06493 (CDK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11931757
S383 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
T387 Phosphorylation PhosphoSitePlus
S417 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
S419 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
S420 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
S421 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231
S427 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K448 Methylation PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
T453 Phosphorylation PhosphoSitePlus
T455 Phosphorylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
S476 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S478 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K540 Ubiquitination PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
K591 Ubiquitination PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
C677 Methylation IEDB 31844290
K698 Ubiquitination PhosphoSitePlus
K711 Ubiquitination PhosphoSitePlus
C733 Methylation IEDB 31844290
S850 Phosphorylation HPRD   PhosphoSitePlus 20068231
K859 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K81 T81 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K149 T149 Biomuta DOID:363 / uterine cancer [ icgc ]
K152 N152 Biomuta DOID:1319 / brain cancer [ icgc ]
S201 F201 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T203 I203 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S217 P217 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S287 Y287 Biomuta DOID:363 / uterine cancer [ icgc ]
T387 N387 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S421 I421 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T453 I453 Biomuta DOID:4362 / cervical cancer [ icgc ]
T455 M455 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K456 E456 Biomuta DOID:363 / uterine cancer [ icgc ]
K540 N540 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C677 Y677 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]