iPTMnet Report for Q13393 (PLD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13393 / PLD1_HUMAN
Protein Name Phospholipase D1
Gene Name Name: PLD1
Organism Homo sapiens (Human)

PRO ID PR:Q13393
DAG View
PRO Name phospholipase D1 (human)
Definition A phospholipase D1 that is encoded in the genome of human.
Short Label hPLD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13393 (PLD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 10441128
S12 Phosphorylation PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
Y42 Phosphorylation PhosphoSitePlus
S45 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K50 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K132 Methylation PhosphoSitePlus
Y133 Phosphorylation IEDB 35494241
T147 Phosphorylation P17252 (PRKCA) RLIMS-P   Signor 18550821, 10441128, 29560412
S162 Phosphorylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K406 Methylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
T495 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
S505 Phosphorylation P54646 (PRKAA2) PhosphoSitePlus   RLIMS-P   Signor 20231899
S508 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S522 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus   RLIMS-P 20231899
K559 Ubiquitination PhosphoSitePlus
S561 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor   UniProt 10441128, 23186163
Y586 Phosphorylation PhosphoSitePlus
Y590 Phosphorylation PhosphoSitePlus
S610 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 11171116
S611 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 11171116
S629 O-Glycosylation GlyGen 31492838
S629 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
T632 O-Glycosylation GlyGen 31492838
T641 O-Glycosylation GlyGen 31492838
K662 Ubiquitination PhosphoSitePlus
K688 Ubiquitination PhosphoSitePlus
Y711 Phosphorylation PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
K807 Acetylation PhosphoSitePlus
K1000 Ubiquitination PhosphoSitePlus
K1027 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation P17252 (PRKCA) HPRD 10441128
S45 Phosphorylation HPRD 18669648
T147 Phosphorylation P17252 (PRKCA) HPRD 10441128
S561 Phosphorylation P17252 (PRKCA) HPRD 10441128
S629 Phosphorylation HPRD 19651622, 17081983
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
K769 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y42 C42 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S45 F45 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T147 M147 Biomuta DOID:4159 / skin cancer [ cosmic ]
K189 N189 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K189 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K501 T501 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S508 F508 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S519 Y519 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S519 F519 Biomuta DOID:4159 / skin cancer [ cosmic ]
S522 F522 Biomuta DOID:4159 / skin cancer [ cosmic ]
K559 R559 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y590 C590 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S611 N611 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T632 R632 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]