Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13370 / PDE3B_HUMAN
Protein Name cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Gene Name Name: PDE3B
Organism Homo sapiens (Human)

PRO ID PR:Q13370
DAG View
PRO Name cGMP-inhibited 3',5'-cyclic phosphodiesterase B (human)
Definition A cGMP-inhibited 3',5'-cyclic phosphodiesterase B that is encoded in the genome of human.
Short Label hPDE3B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13370 (PDE3B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
S73 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 17255105
S279 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
S295 Phosphorylation P31749 (AKT1) neXtProt   PRO   PhosphoSitePlus   Signor 10454575
S296 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 17255105
S299 Phosphorylation PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
S318 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus 8626720, 8163498, 17255105
S323 Phosphorylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus
S442 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
T444 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S445 Phosphorylation PhosphoSitePlus
T487 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
T561 Phosphorylation PhosphoSitePlus
Y565 Phosphorylation PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
Y586 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
Y751 Phosphorylation PhosphoSitePlus
T769 Phosphorylation PhosphoSitePlus
T773 Phosphorylation PhosphoSitePlus
K943 Ubiquitination PhosphoSitePlus
S981 Phosphorylation PhosphoSitePlus
K1073 Ubiquitination PhosphoSitePlus
K1081 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S295 Phosphorylation P31749 (AKT1) HPRD 10454575
S318 Phosphorylation P17612 (PRKACA) , P31749 (AKT1) HPRD 8626720, 8163498, 10454575
S442 Phosphorylation P31749 (AKT1) HPRD 18669648, 10454575
T444 Phosphorylation HPRD 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048719 (hPDE3B/Phos:1) pS295 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S65 Y65 Biomuta DOID:1324 / lung cancer [ cosmic ]
S279 F279 Biomuta DOID:10534 / stomach cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]
S280 N280 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S299 P299 Biomuta DOID:363 / uterine cancer [ tcga ]
S299 W299 Biomuta DOID:1324 / lung cancer [ tcga ]
S318 L318 Biomuta DOID:3571 / liver cancer [ icgc ]
S371 I371 Biomuta DOID:363 / uterine cancer [ tcga ]
S378 F378 Biomuta DOID:1909 / melanoma [ tcga ]
S379 F379 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
K426 N426 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:1324 / lung cancer [ cosmic ]
S495 F495 Biomuta DOID:1324 / lung cancer [ cosmic ]
S495 Y495 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
T561 P561 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y565 C565 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S573 N573 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S578 C578 Biomuta DOID:1324 / lung cancer [ cosmic ]
K585 T585 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S602 T602 Biomuta DOID:1324 / lung cancer [ cosmic ]
S613 A613 Biomuta DOID:1909 / melanoma [ cosmic ]
Y751 * Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K1081 Q1081 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]