Protein Information

Cytoscape View

UniProt AC / UniProt ID Q13363 / CTBP1_HUMAN
Protein Name C-terminal-binding protein 1
Gene Name Name: CTBP1
Organism Homo sapiens (Human)

PRO ID PR:Q13363
DAG View
PRO Name C-terminal-binding protein 1 (human)
Definition A C-terminal-binding protein 1 that is encoded in the genome of human.
Short Label hCTBP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q13363 (CTBP1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K46 Ubiquitination PhosphoSitePlus
C54 S-Nitrosylation dbSNO 24105792
Y76 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
S158 Phosphorylation Q13153 (PAK1) , Q13131 (PRKAA1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 26416879, 23291169, 12872159
K194 Ubiquitination PhosphoSitePlus
R266 Methylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
R285 Methylation PhosphoSitePlus
S300 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
K348 Ubiquitination PhosphoSitePlus
C350 S-Nitrosylation dbSNO 24105792
S422 Phosphorylation P45983 (MAPK8) , Q9H2X6 (HIPK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16984892, 14567915, 15708980, ...33613771
K428 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S300 Phosphorylation HPRD 17525332
Y381 Phosphorylation HPRD 20068231
S422 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
R5 Methylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
S289 Phosphorylation HPRD 17525332
Y370 Phosphorylation HPRD 20068231
S411 Phosphorylation HPRD 20068231

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13363 (CTBP1) S422 P37275 (ZEB1) unknown eFIP 21224849

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R266 W266 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
R285 C285 Biomuta DOID:4362 / cervical cancer [ tcga ]
C350 G350 Biomuta DOID:263 / kidney cancer [ icgc, tcga ]