iPTMnet Report for Q13362 (PPP2R5C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13362 / 2A5G_HUMAN
Protein Name Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Gene Name Name: PPP2R5C
Synonyms:KIAA0044;
Organism Homo sapiens (Human)

PRO ID PR:Q13362
DAG View
PRO Name serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (human)
Definition A serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform that is encoded in the genome of human.
Short Label hPPP2R5C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13362 (PPP2R5C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K6 Ubiquitination PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
Y79 Phosphorylation PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
Y209 Phosphorylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus 19366811
S298 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 19366811
K333 Ubiquitination PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus 19366811
S336 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 19366811
S337 Phosphorylation PRO   Signor 16456541
S337 Phosphorylation P27361 (MAPK3) Signor 16456541
S337 Phosphorylation P28482 (MAPK1) Signor 16456541
Y348 Phosphorylation PhosphoSitePlus
Y349 Phosphorylation PhosphoSitePlus
Y354 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
Y375 Phosphorylation PhosphoSitePlus
T385 Phosphorylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
C408 Methylation IEDB 31844290
K413 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K487 Acetylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus 21460856
S520 Phosphorylation Q13315 (ATM) PhosphoSitePlus 21460856
Site PTM Type PTM Enzyme Score Source PMID
S458 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048889 (hPPP2R5C/Phos:1) pS337 PRO


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q5FBB7 (hSGO1) Interaction PR:Q13362 (hPPP2R5C) PRO 16580887


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K6 R6 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K333 T333 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S336 Y336 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S336 F336 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K432 N432 Biomuta DOID:363 / uterine cancer [ icgc ]
S458 A458 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S497 A497 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S513 A513 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]