Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13356 / PPIL2_HUMAN
Protein Name RING-type E3 ubiquitin-protein ligase PPIL2
Gene Name Name: PPIL2
Organism Homo sapiens (Human)

PRO ID PR:Q13356
DAG View
PRO Name RING-type E3 ubiquitin-protein ligase PPIL2 (human)
Definition A RING-type E3 ubiquitin-protein ligase PPIL2 that is encoded in the genome of human.
Short Label hPPIL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13356 (PPIL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y12 Phosphorylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
Y212 Phosphorylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K216 Sumoylation PhosphoSitePlus
K226 Acetylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K230 Acetylation PhosphoSitePlus
K231 Acetylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
K460 Sumoylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus   UniProt 23186163
K482 Acetylation PhosphoSitePlus   UniProt 19608861
K482 Ubiquitination PhosphoSitePlus
K490 Acetylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
R512 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K482 Acetylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S170 F170 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y212 N212 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K235 N235 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K482 M482 Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
R512 W512 Biomuta DOID:2531 / hematologic cancer [ icgc ]