iPTMnet Report for Q13356 (PPIL2)
Protein Information
| UniProt AC / UniProt ID | Q13356 / PPIL2_HUMAN |
| Protein Name | RING-type E3 ubiquitin-protein ligase PPIL2 |
| Gene Name | Name: PPIL2 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q13356 |
| PRO Name | RING-type E3 ubiquitin-protein ligase PPIL2 (human) |
| Definition | A RING-type E3 ubiquitin-protein ligase PPIL2 that is encoded in the genome of human. |
| Short Label | hPPIL2 |
| Category | organism-gene |
DAG ViewQ13356 (PPIL2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y12 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K72 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K82 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K90 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K95 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K139 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K166 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S170 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K176 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K180 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K190 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S194 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K198 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y212 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K213 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K216 | Sumoylation | score1 | PhosphoSitePlus | |||
| K226 | Acetylation | score1 | PhosphoSitePlus | |||
| K226 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K230 | Acetylation | score1 | PhosphoSitePlus | |||
| K231 | Acetylation | score1 | PhosphoSitePlus | |||
| K235 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y241 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y281 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T286 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K313 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K393 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T395 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S415 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T459 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K460 | Sumoylation | score1 | PhosphoSitePlus | |||
| K462 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S470 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K482 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K482 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K490 | Acetylation | score1 | PhosphoSitePlus | |||
| K490 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R512 | Methylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K482 | Acetylation | score1 | PhosphoSitePlus | |||
| S495 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S502 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S508 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y12 | H12 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K82 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] | |
| S170 | F170 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| Y212 | N212 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| K235 | N235 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| T286 | I286 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K313 | Q313 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S415 | T415 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| S470 | N470 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K482 | M482 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| R512 | W512 | Biomuta | DOID:1612 / breast cancer [ cosmic ] |
