iPTMnet Report for Q13342 (SP140)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13342 / SP140_HUMAN
Protein Name Nuclear body protein SP140
Gene Name Name: SP140
Synonyms:LYSP100;
Organism Homo sapiens (Human)

PRO ID PR:Q13342
DAG View
PRO Name nuclear body protein SP140 (human)
Definition A nuclear body protein SP140 that is encoded in the genome of human.
Short Label hSP140
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13342 (SP140) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus
T308 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
T365 Phosphorylation PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
T483 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
K535 Acetylation PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
T726 Phosphorylation IntAct   UniProt 24267382
K736 Ubiquitination PhosphoSitePlus
S741 Phosphorylation PhosphoSitePlus
Y784 Phosphorylation PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13342 (SP140) T726 Q13526 (PIN1) unknown eFIP 24267382


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K535 N535 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K535 R535 Biomuta DOID:1909 / melanoma [ tcga ]
K736 N736 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]