Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13309 / SKP2_HUMAN
Protein Name S-phase kinase-associated protein 2
Gene Name Name: SKP2
Synonyms:FBXL1;
Organism Homo sapiens (Human)

PRO ID PR:Q13309
DAG View
PRO Name S-phase kinase-associated protein 2 (human)
Definition An S-phase kinase-associated protein 2 that is encoded in the genome of human.
Short Label hSKP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13309 (SKP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K43 Sumoylation PhosphoSitePlus
S48 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S57 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S64 Phosphorylation P11309 (PIM1) , P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 23186163, ...17081983, 9858587, 20160477, 20663873, 18239684, 18669648, 23807222, 28446188, 20160482, 20068231, 25271736
K68 Acetylation PhosphoSitePlus   UniProt 22770219
K71 Acetylation PhosphoSitePlus   UniProt 22770219
S72 Phosphorylation P31749 (AKT1) , P11309 (PIM1) neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 26636645, 23186163, 25271736, ...19270695, 19549334, 18239684, 20160477, 20160482, 23807222, 20663873
K73 Ubiquitination PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus   UniProt 23186163
K77 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
S179 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
S212 Phosphorylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
T417 Phosphorylation P11309 (PIM1) neXtProt   PhosphoSitePlus   RLIMS-P 20663873
K420 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S48 Phosphorylation HPRD 18669648
S57 Phosphorylation HPRD 18669648
S64 Phosphorylation HPRD 18691976, 18452278, 19651622, ...17322306, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S48 Phosphorylation HPRD 18669648
S57 Phosphorylation HPRD 18669648
S64 Phosphorylation HPRD 18691976, 18452278, 19651622, ...17322306, 18669648, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P46414 (Cdkn1b) T187 Q13309 (SKP2) increasedassociation eFIP 14680481
Phosphorylation Q03164 (KMT2A) S516 Q13309 (SKP2) unknown eFIP 20818375
Phosphorylation Q13309 (SKP2) S64 P12830 (CDH1) inhibited_association eFIP 18239684
Phosphorylation Q13309 (SKP2) S64 P12830 (CDH1) inhibited_association eFIP 23807222
Phosphorylation Q13309 (SKP2) S72 P12830 (CDH1) inhibited_association eFIP 23807222
Phosphorylation Q9H211 (CDT1) T29 Q13309 (SKP2) unknown eFIP 17565698


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036472 (hRBL2/iso:1/Phos:2) Interaction PR:Q13309 (hSKP2) PRO 12006580
PR:000036472 (hRBL2/iso:1/Phos:2) Interaction PR:Q13309 (hSKP2) PRO 12006580
PR:000036472 (hRBL2/iso:1/Phos:2) Interaction PR:Q13309 (hSKP2) PRO 12006580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K125 N125 Biomuta DOID:1324 / lung cancer [ tcga ]
S179 G179 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]