iPTMnet Report for Q13257 (MAD2L1)
Protein Information
| UniProt AC / UniProt ID | Q13257 / MD2L1_HUMAN |
| Protein Name | Mitotic spindle assembly checkpoint protein MAD2A |
| Gene Name | Name: MAD2L1 Synonyms:MAD2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q13257 |
| PRO Name | mitotic spindle assembly checkpoint protein MAD2A (human) |
| Definition | A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of human. |
| Short Label | hMAD2L1 |
| Category | organism-gene |
DAG ViewQ13257 (MAD2L1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S6 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| T42 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K48 | Acetylation | score1 | IEDB | 34357683 | ||
| Y77 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C106 | S-Nitrosylation | score0 | dbSNO | 19483679 | ||
| K108 | Acetylation | score1 | PhosphoSitePlus | |||
| K108 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K111 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K119 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K122 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R129 | Methylation | score1 | PhosphoSitePlus | |||
| S130 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K166 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S170 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 32637030, 12574116 | ||
| S178 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 32637030, 12574116 | ||
| S185 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 32637030, 23454898, 23186163 | ||
| S185 | Phosphorylation | O14757 (CHEK1) | score2 | PhosphoSitePlus | 23454898 | |
| T187 | Phosphorylation | score2 | PhosphoSitePlus | 23454898 | ||
| T187 | Phosphorylation | O14757 (CHEK1) | score2 | PhosphoSitePlus | 23454898 | |
| K192 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S195 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 21041666, 23186163, 35309941, ... | ||
| Y199 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K200 | Ubiquitination | score1 | PhosphoSitePlus |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000035369 (hCDC20/PhosRes-) | Interaction | PR:Q13257 (hMAD2L1) | PRO | 15525512 | |
| PR:000035371 (hCDC20/Phos:1) | Interaction | PR:Q13257 (hMAD2L1) | PRO | 15525512 | |
| PR:O43684 (hBUB3) | Interaction | PR:Q13257 (hMAD2L1) | PRO | ||
| PR:O60566 (hBUB1B) | Interaction | PR:Q13257 (hMAD2L1) | PRO | 20624902 | |
| PR:P25054 (hAPC) | Interaction | PR:Q13257 (hMAD2L1) | PRO | ||
| PR:Q12834 (hCDC20) | Interaction | PR:Q13257 (hMAD2L1) | PRO | 20624902 | |
| PR:Q13257 (hMAD2L1) | Interaction | PR:O43684 (hBUB3) | PRO | ||
| PR:Q13257 (hMAD2L1) | Interaction | PR:P25054 (hAPC) | PRO | ||
| PR:Q13257 (hMAD2L1) | Interaction | PR:Q12834 (hCDC20) | PRO | 20624902 | |
| PR:Q13257 (hMAD2L1) | Interaction | PR:O60566 (hBUB1B) | PRO | 20624902 | |
| PR:Q13257 (hMAD2L1) | Interaction | PR:Q9Y6D9 (hMAD1L1) | PRO | ||
| PR:Q9Y6D9 (hMAD1L1) | Interaction | PR:Q13257 (hMAD2L1) | PRO | 10198256 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K48 | * | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
| Y77 | F77 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| Y77 | H77 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| K108 | M108 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| R129 | C129 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
| S130 | * | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S170 | L170 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S185 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S195 | G195 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |
