iPTMnet Report for Q13255 (GRM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13255 / GRM1_HUMAN
Protein Name Metabotropic glutamate receptor 1 precursor
Gene Name Name: GRM1
Synonyms:GPRC1A,MGLUR1;
Organism Homo sapiens (Human)

PRO ID PR:Q13255
DAG View
PRO Name metabotropic glutamate receptor 1 (human)
Definition A metabotropic glutamate receptor 1 that is encoded in the genome of human.
Short Label hGRM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13255 (GRM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T620 Phosphorylation PhosphoSitePlus
Y632 Phosphorylation PhosphoSitePlus
Y672 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
T677 Phosphorylation PhosphoSitePlus
T695 Phosphorylation P17252 (PRKCA) phospho.ELM   Signor 10823959
K740 Methylation PhosphoSitePlus
S869 Phosphorylation PhosphoSitePlus
T871 Phosphorylation PhosphoSitePlus   RLIMS-P 23426668
K891 Ubiquitination PhosphoSitePlus
S914 Phosphorylation IEDB 35494241
Y1109 Phosphorylation PhosphoSitePlus
Y1111 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y632 C632 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y672 C672 Biomuta DOID:1319 / brain cancer [ cosmic ]
T695 S695 Biomuta DOID:3571 / liver cancer [ cosmic ]
K740 N740 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S914 Y914 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
Y1111 C1111 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y1111 F1111 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]