Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13247 / SRSF6_HUMAN
Protein Name Serine/arginine-rich splicing factor 6
Gene Name Name: SRSF6
Synonyms:SFRS6,SRP55;
Organism Homo sapiens (Human)

PRO ID PR:Q13247
DAG View
PRO Name serine/arginine-rich splicing factor 6 (human)
Definition A serine/arginine-rich splicing factor 6 that is encoded in the genome of human.
Short Label hSRSF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13247 (SRSF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation PhosphoSitePlus
S45 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24275569
Y53 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
R71 Methylation PhosphoSitePlus
Y80 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y82 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus   UniProt 21406692
R85 Methylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
Y91 Phosphorylation PhosphoSitePlus
R94 Methylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
K101 Acetylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
T137 Phosphorylation PhosphoSitePlus
Y138 Phosphorylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
K165 Acetylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
K182 Acetylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
Y191 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S259 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S261 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
Y269 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K290 Acetylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
S297 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S299 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S301 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935, 17081983
S303 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 17287340, 22767602, 19690332, 20068231
S310 Phosphorylation PhosphoSitePlus
S314 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...15302935, 18669648, 20068231
S316 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...15302935, 18669648, 20068231
S324 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S45 Phosphorylation HPRD 19664994, 17081983, 18452278
S81 Phosphorylation HPRD 20068231
S118 Phosphorylation HPRD 17081983, 20068231
S119 Phosphorylation HPRD 17081983, 20068231, 18452278
S257 Phosphorylation HPRD 19651622, 20068231
S259 Phosphorylation HPRD 19651622, 17081983
S261 Phosphorylation HPRD 19651622
S263 Phosphorylation HPRD 19651622
S265 Phosphorylation HPRD 20068231
S295 Phosphorylation HPRD 20068231
S297 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S299 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S301 Phosphorylation HPRD 19413330, 17322306, 18452278, ...19651622, 18669648, 20068231
S303 Phosphorylation HPRD 19413330, 17322306, 17287340, ...18212344, 18767875, 19664994, 19691289, 19007248, 19651622, 18669648, 19664995, 18452278, 17924679, 20068231, 20058876
S314 Phosphorylation HPRD 17287340, 18212344, 15302935, ...19651622, 18669648, 20166139, 20068231
S316 Phosphorylation HPRD 17287340, 18212344, 15302935, ...18452278, 19651622, 18669648, 20166139, 20068231
T323 Phosphorylation HPRD 20068231
S324 Phosphorylation HPRD 17081983, 20068231
S326 Phosphorylation HPRD 17081983, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T146 I146 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S196 Y196 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
Y269 C269 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:1324 / lung cancer [ cosmic, tcga ]
K290 N290 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
S291 P291 Biomuta DOID:363 / uterine cancer [ tcga ]
S291 * Biomuta DOID:4362 / cervical cancer [ icgc, tcga ]
S301 Y301 Biomuta DOID:10534 / stomach cancer [ tcga ]
S301 P301 Biomuta DOID:1324 / lung cancer [ tcga ]
S303 L303 Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:263 / kidney cancer [ tcga ]
S310 A310 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T323 P323 Biomuta DOID:4362 / cervical cancer [ tcga ]