iPTMnet Report for Q13237 (PRKG2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13237 / KGP2_HUMAN
Protein Name cGMP-dependent protein kinase 2
Gene Name Name: PRKG2
Synonyms:PRKGR2;
Organism Homo sapiens (Human)

PRO ID PR:Q13237
DAG View
PRO Name cGMP-dependent protein kinase 2 (human)
Definition A cGMP-dependent protein kinase 2 that is encoded in the genome of human.
Short Label hPRKG2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13237 (PRKG2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 8636133
S11 Phosphorylation PhosphoSitePlus
S97 Phosphorylation neXtProt 12764134
S97 Phosphorylation Q13237 (PRKG2) neXtProt 12764134
T109 Phosphorylation PhosphoSitePlus
S110 Phosphorylation neXtProt   PhosphoSitePlus 12764134
S110 Phosphorylation Q13237 (PRKG2) neXtProt 12764134
S114 Phosphorylation neXtProt 12764134
S114 Phosphorylation Q13237 (PRKG2) neXtProt 12764134
S117 Phosphorylation neXtProt   PhosphoSitePlus 12764134
S117 Phosphorylation Q13237 (PRKG2) neXtProt 12764134
S126 Phosphorylation neXtProt 12764134
S126 Phosphorylation Q13237 (PRKG2) neXtProt 12764134
T131 Phosphorylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K165 Sumoylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
Y306 Phosphorylation PhosphoSitePlus
Y307 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
S445 Phosphorylation neXtProt 12764134
S445 Phosphorylation Q13237 (PRKG2) neXtProt 12764134
S448 Phosphorylation PhosphoSitePlus
K521 Methylation PhosphoSitePlus


Q13237 (PRKG2) as PTM Enzyme



Substrate Site Score Source PMID
P04626 (ERBB2) T686 PhosphoSitePlus 26676300
P04792 (HSPB1) S78 Signor 19593530
P04792 (HSPB1) S82 Signor 19593530
P04792 (HSPB1) T143 Signor 19593530
P29474 (NOS3) T495 PhosphoSitePlus 10671564
P29474 (NOS3) S633 PhosphoSitePlus 10671564
P29474 (NOS3) S1177 neXtProt   PhosphoSitePlus 18551195, 10671564
P30307 (CDC25C) S216 neXtProt 18551195
P32929 (CTH) S377 PhosphoSitePlus 25900831
P42261 (GRIA1) S863 neXtProt 18031684
P48436 (SOX9) S181 neXtProt 15466490
P49675 (STAR) S56 neXtProt 12775716
P49675 (STAR) S57 neXtProt 12775716
P49675 (STAR) S100 neXtProt 12775716
P49841 (GSK3B) S9 neXtProt 18551195
P50552 (VASP) S239 neXtProt 18551195
P53350 (PLK1) S137 neXtProt 18551195
P55211 (CASP9) S196 neXtProt 18551195
Q01970-1 (PLCB3) S26 HPRD 11278298
Q01970-1 (PLCB3) S1105 HPRD 19651622, 11278298
Q03393 (PTS) S19 HPRD   neXtProt   PhosphoSitePlus   Signor 20166139, 10531334, 20068231, ...7493990
Q12778 (FOXO1) S319 neXtProt 22393355
Q13237 (PRKG2) S97 neXtProt 12764134
Q13237 (PRKG2) S110 neXtProt 12764134
Q13237 (PRKG2) S114 neXtProt 12764134
Q13237 (PRKG2) S117 neXtProt 12764134
Q13237 (PRKG2) S126 neXtProt 12764134
Q13237 (PRKG2) S445 neXtProt 12764134
Q14847-1 (LASP1) S61 HPRD 12571245
Q14847 (LASP1) S146 HPRD   PhosphoSitePlus   Signor 17287340, 18212344, 12571245, ...18077418, 18669648, 20166139, 18088087, 20068231
Q15418 (RPS6KA1) S380 neXtProt 18551195
Q9UL51 (HCN2) S668 neXtProt 21347269


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
G2 E2 Biomuta DOID:4159 / skin cancer [ cosmic ]
S11 F11 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S97 F97 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S110 F110 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S114 F114 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K157 N157 Biomuta DOID:1324 / lung cancer [ cosmic ]
S445 Y445 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S445 F445 Biomuta DOID:4159 / skin cancer [ cosmic ]
K521 M521 Biomuta DOID:1324 / lung cancer [ cosmic ]
K521 T521 Biomuta DOID:4159 / skin cancer [ cosmic ]