iPTMnet Report Q13237 PRKG2

Protein Information

UniProt AC / UniProt ID	Q13237 / KGP2_HUMAN
Protein Name	cGMP-dependent protein kinase 2
Gene Name	Name: PRKG2 Synonyms:PRKGR2;
Organism	Homo sapiens (Human)

PRO ID	PR:Q13237 DAG View
PRO Name	cGMP-dependent protein kinase 2 (human)
Definition	A cGMP-dependent protein kinase 2 that is encoded in the genome of human.
Short Label	hPRKG2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q13237 (PRKG2) as Substrate

Q13237

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position G2 S11 S97 T109 S110 S114 S117 S126 T131 K157 K165 Y306 Y307 S431 S445 S448 K521	PTM Type Select all Methylation Myristoylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme Select all Q13237 (PRKG2)	Score Select all 1 2 3	Source Select all PhosphoSitePlus UniProt neXtProt	PMID
G2	Myristoylation		score2	UniProt	8636133
S11	Phosphorylation		score1	PhosphoSitePlus
S97	Phosphorylation		score2	neXtProt	12764134
S97	Phosphorylation	Q13237 (PRKG2)	score2	neXtProt	12764134
T109	Phosphorylation		score1	PhosphoSitePlus
S110	Phosphorylation		score3	neXtProt PhosphoSitePlus	12764134
S110	Phosphorylation	Q13237 (PRKG2)	score2	neXtProt	12764134
S114	Phosphorylation		score2	neXtProt	12764134
S114	Phosphorylation	Q13237 (PRKG2)	score2	neXtProt	12764134
S117	Phosphorylation		score3	neXtProt PhosphoSitePlus	12764134
S117	Phosphorylation	Q13237 (PRKG2)	score2	neXtProt	12764134
S126	Phosphorylation		score2	neXtProt	12764134
S126	Phosphorylation	Q13237 (PRKG2)	score2	neXtProt	12764134
T131	Phosphorylation		score1	PhosphoSitePlus
K157	Ubiquitination		score1	PhosphoSitePlus
K165	Sumoylation		score1	PhosphoSitePlus
K165	Ubiquitination		score1	PhosphoSitePlus
Y306	Phosphorylation		score1	PhosphoSitePlus
Y307	Phosphorylation		score1	PhosphoSitePlus
S431	Phosphorylation		score1	PhosphoSitePlus
S445	Phosphorylation		score2	neXtProt	12764134
S445	Phosphorylation	Q13237 (PRKG2)	score2	neXtProt	12764134
S448	Phosphorylation		score1	PhosphoSitePlus
K521	Methylation		score1	PhosphoSitePlus

Q13237 (PRKG2) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all P04626 (ERBB2) P04792 (HSPB1) P29474 (NOS3) P30307 (CDC25C) P32929 (CTH) P42261 (GRIA1) P48436 (SOX9) P49675 (STAR) P49841 (GSK3B) P50552 (VASP) P53350 (PLK1) P55211 (CASP9) Q01970-1 (PLCB3) Q03393 (PTS) Q12778 (FOXO1) Q13237 (PRKG2) Q14847 (LASP1) Q14847-1 (LASP1) Q15418 (RPS6KA1) Q9UL51 (HCN2)	Site Select all By amino acid All Serine All Threonine By position S9 S19 S26 S56 S57 S61 S78 S82 S97 S100 S110 S114 S117 S126 S137 T143 S146 S181 S196 S216 S239 S319 S377 S380 S445 T495 S633 S668 T686 S863 S1105 S1177	Score Select all 1 2 4	Source Select all HPRD PhosphoSitePlus Signor neXtProt	PMID
P04626 (ERBB2)	T686	score2	PhosphoSitePlus	26676300
P04792 (HSPB1)	S78	score1	Signor	19593530
P04792 (HSPB1)	S82	score1	Signor	19593530
P04792 (HSPB1)	T143	score1	Signor	19593530
P29474 (NOS3)	T495	score2	PhosphoSitePlus	10671564
P29474 (NOS3)	S633	score2	PhosphoSitePlus	10671564
P29474 (NOS3)	S1177	score4	neXtProt PhosphoSitePlus	18551195, 10671564
P30307 (CDC25C)	S216	score2	neXtProt	18551195
P32929 (CTH)	S377	score2	PhosphoSitePlus	25900831
P42261 (GRIA1)	S863	score2	neXtProt	18031684
P48436 (SOX9)	S181	score2	neXtProt	15466490
P49675 (STAR)	S56	score2	neXtProt	12775716
P49675 (STAR)	S57	score2	neXtProt	12775716
P49675 (STAR)	S100	score2	neXtProt	12775716
P49841 (GSK3B)	S9	score2	neXtProt	18551195
P50552 (VASP)	S239	score2	neXtProt	18551195
P53350 (PLK1)	S137	score2	neXtProt	18551195
P55211 (CASP9)	S196	score2	neXtProt	18551195
Q01970-1 (PLCB3)	S26	score1	HPRD	11278298
Q01970-1 (PLCB3)	S1105	score2	HPRD	19651622, 11278298
Q03393 (PTS)	S19	score4	HPRD neXtProt PhosphoSitePlus Signor	20166139, 10531334, 20068231, ...7493990
Q12778 (FOXO1)	S319	score2	neXtProt	22393355
Q13237 (PRKG2)	S97	score2	neXtProt	12764134
Q13237 (PRKG2)	S110	score2	neXtProt	12764134
Q13237 (PRKG2)	S114	score2	neXtProt	12764134
Q13237 (PRKG2)	S117	score2	neXtProt	12764134
Q13237 (PRKG2)	S126	score2	neXtProt	12764134
Q13237 (PRKG2)	S445	score2	neXtProt	12764134
Q14847-1 (LASP1)	S61	score1	HPRD	12571245
Q14847 (LASP1)	S146	score4	HPRD PhosphoSitePlus Signor	17287340, 18212344, 12571245, ...18077418, 18669648, 20166139, 18088087, 20068231
Q15418 (RPS6KA1)	S380	score2	neXtProt	18551195
Q9UL51 (HCN2)	S668	score2	neXtProt	21347269

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine By position G2 S11 S97 S110 S114 K157 S445 K521	Variant Select all E2 F11 F110 F114 F445 F97 M521 N157 T521 Y445	Source Select all Biomuta	Disease [Sample source] Select all DOID:1324 / lung cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
G2	E2	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S11	F11	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S97	F97	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
S110	F110	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S114	F114	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
K157	N157	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S445	Y445	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S445	F445	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K521	M521	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K521	T521	Biomuta	DOID:4159 / skin cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q13237 (PRKG2)

Protein Information

Interactive Sequence View

Q13237 (PRKG2) as Substrate

Q13237 (PRKG2) as PTM Enzyme

PTM sites affected in variants