iPTMnet Report for Q13233 (MAP3K1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13233 / M3K1_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 1
Gene Name Name: MAP3K1
Synonyms:MAPKKK1,MEKK,MEKK1;
Organism Homo sapiens (Human)

PRO ID PR:Q13233
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 1 (human)
Definition A mitogen-activated protein kinase kinase kinase 1 that is encoded in the genome of human.
Short Label hMAP3K1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13233 (MAP3K1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
T20 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus   UniProt 23186163
S35 Phosphorylation PhosphoSitePlus   UniProt 23186163
S67 Phosphorylation P01116 (KRAS) , Q13153 (PAK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 12228228, 8649450
S133 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus   UniProt 18691976
S232 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
T261 Phosphorylation RLIMS-P 27486656, 29499695
S264 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
S281 Phosphorylation PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus   UniProt 23186163
S292 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 23186163, ...18220336
S297 O-Glycosylation GlyGen 29351928
S297 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S300 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S333 Phosphorylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
K436 Sumoylation PhosphoSitePlus
S507 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S511 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T522 Phosphorylation PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus   UniProt 23186163
T542 Phosphorylation PhosphoSitePlus
C643 Methylation IEDB 31844290
T657 Phosphorylation PhosphoSitePlus
T665 Phosphorylation PhosphoSitePlus
T686 Phosphorylation PhosphoSitePlus
K690 Ubiquitination PhosphoSitePlus
S796 Phosphorylation PhosphoSitePlus
S844 Phosphorylation PhosphoSitePlus
T850 Phosphorylation PhosphoSitePlus
K919 Ubiquitination PhosphoSitePlus
S921 Phosphorylation PhosphoSitePlus
S923 Phosphorylation PhosphoSitePlus   UniProt 23186163
S928 Phosphorylation PhosphoSitePlus
S940 O-Glycosylation GlyGen 32938750
S970 Phosphorylation Q13546 (RIPK1) Signor 11369754
T999 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
S1018 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S1026 Phosphorylation PhosphoSitePlus
S1043 Phosphorylation PhosphoSitePlus   UniProt 18691976
T1082 Phosphorylation PhosphoSitePlus
S1087 Phosphorylation PhosphoSitePlus
S1089 Phosphorylation PhosphoSitePlus
T1114 Phosphorylation PhosphoSitePlus
S1157 Phosphorylation PhosphoSitePlus
K1168 Ubiquitination PhosphoSitePlus
K1176 Ubiquitination PhosphoSitePlus
Y1338 Phosphorylation PhosphoSitePlus
K1371 Ubiquitination PhosphoSitePlus
K1398 Ubiquitination PhosphoSitePlus
T1400 Phosphorylation PRO
T1412 Phosphorylation PRO
S1455 Phosphorylation PhosphoSitePlus
S1472 Phosphorylation IEDB 32387766
S1478 Phosphorylation IEDB 32387766


Q13233 (MAP3K1) as PTM Enzyme



Substrate Site Score Source PMID
O14733 (MAP2K7) S271 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 22903704, 9312068, 17110930, ...10713157
O14733 (MAP2K7) T275 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 22903704, 17110930, 9312068, ...10713157
P40763 (STAT3) S727 Signor 17563747
P45985 (MAP2K4) T261 Signor 9712898
P52564 (MAP2K6) T211 Signor 9712898
Q02750 (MAP2K1) S218 neXtProt 8034665
Q02750 (MAP2K1) S222 neXtProt 8034665
Q13158 (FADD) S194 PhosphoSitePlus   Signor 15001534
Q8NHW3 (MAFA) S14 PhosphoSitePlus 11416124
Q8NHW3 (MAFA) S65 PhosphoSitePlus 11416124


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048303 (hMAP3K1/InitMet-/Phos:1) pT1400,pT1412 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S133 G133 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S232 F232 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S266 F266 Biomuta DOID:4159 / skin cancer [ cosmic ]
S275 F275 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
T285 K285 Biomuta DOID:1612 / breast cancer [ cosmic ]
S292 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S292 P292 Biomuta DOID:4159 / skin cancer [ cosmic ]
S292 L292 Biomuta DOID:1612 / breast cancer [ cosmic ]
S297 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S333 I333 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S431 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S531 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S531 L531 Biomuta DOID:4159 / skin cancer [ cosmic ]
T657 A657 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K690 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K690 I690 Biomuta DOID:1324 / lung cancer [ cosmic ]
S796 F796 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S844 F844 Biomuta DOID:4159 / skin cancer [ cosmic ]
S844 P844 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S923 N923 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S928 Y928 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T999 I999 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1016 F1016 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S1026 Y1026 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S1043 F1043 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1087 N1087 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T1114 I1114 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1371 E1371 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1455 P1455 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1455 F1455 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1472 L1472 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1478 Y1478 Biomuta DOID:363 / uterine cancer [ icgc ]