Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13224 / NMDE2_HUMAN
Protein Name Glutamate receptor ionotropic, NMDA 2B precursor
Gene Name Name: GRIN2B
Synonyms:NMDAR2B;
Organism Homo sapiens (Human)

PRO ID PR:Q13224
DAG View
PRO Name glutamate receptor ionotropic, NMDA 2B (human)
Definition A glutamate receptor ionotropic, NMDA 2B that is encoded in the genome of human.
Short Label hGRIN2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13224 (GRIN2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
S383 Phosphorylation Q13554 (CAMK2B) , Q9UQM7 (CAMK2A) HPRD   RLIMS-P 8940188
T475 Phosphorylation PhosphoSitePlus
T493 Phosphorylation PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
T760 Phosphorylation PhosphoSitePlus
Y762 Phosphorylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
Y932 Phosphorylation P06241 (FYN) HPRD 11024032
Y1039 Phosphorylation P06241 (FYN) HPRD   PhosphoSitePlus 11024032
S1043 Phosphorylation PhosphoSitePlus
Y1070 Phosphorylation P06241 (FYN) HPRD   RLIMS-P 28326942, 26229100, 11024032
Y1109 Phosphorylation P06241 (FYN) HPRD 11024032
S1116 Phosphorylation RLIMS-P 24607229
S1166 Phosphorylation PhosphoSitePlus   RLIMS-P 24431445
S1168 Phosphorylation PhosphoSitePlus
T1183 Phosphorylation PhosphoSitePlus
S1191 Phosphorylation PhosphoSitePlus
Y1252 Phosphorylation P06241 (FYN) HPRD   neXtProt   PRO   Signor 16190898, 11024032, 18691323
K1280 Acetylation PhosphoSitePlus
S1284 Phosphorylation RLIMS-P 28359951
K1289 Acetylation PhosphoSitePlus
S1303 Phosphorylation P17252 (PRKCA) , P05771 (PRKCB) , P53355 (DAPK1) , Q13554 (CAMK2B) , P05129 (PRKCG) , Q9UQM7 (CAMK2A) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 27634008, 28439098, 25941471, ...12147342, 25052836, 17145509, 19086921, 20353941, 15866054, 21610080, 23085545, 27998718, 10764765, 28731405, 20141836, 11306676, 8940188, 22427672, 22479519
Y1304 Phosphorylation PhosphoSitePlus
T1306 Phosphorylation PhosphoSitePlus
S1323 Phosphorylation P05129 (PRKCG) , P17252 (PRKCA) , P05771 (PRKCB) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 11306676, 25941471, 22179603
Y1336 Phosphorylation P06241 (FYN) HPRD   neXtProt   PRO   RLIMS-P   Signor 16190898, 18691323, 17526495, ...11024032
T1410 Phosphorylation PhosphoSitePlus
S1432 Phosphorylation PhosphoSitePlus
S1469 Phosphorylation PhosphoSitePlus
Y1474 Phosphorylation P12931 (SRC) , P06241 (FYN) , P29323 (EPHB2) HPRD   neXtProt   PRO   PhosphoSitePlus   Signor 11024032, 18691323, 19661068, ...16190898, 11483655
S1479 Phosphorylation P68400 (CSNK2A1) Signor 15537897
S1482 Phosphorylation neXtProt 20869595


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047623 (hGRIN2B/SigPep-/Phos:1) pY1252,pY1336,pY1474 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S34 N34 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y239 F239 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S383 P383 Biomuta DOID:1909 / melanoma [ tcga ]
T475 N475 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
T514 P514 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S770 F770 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S770 Y770 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
Y932 N932 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y1039 N1039 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
S1043 T1043 Biomuta DOID:1909 / melanoma [ tcga ]
Y1070 N1070 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S1168 R1168 Biomuta DOID:1324 / lung cancer [ tcga ]
T1183 M1183 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
K1280 E1280 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S1284 R1284 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1303 P1303 Biomuta DOID:3571 / liver cancer [ icgc ]
Y1336 C1336 Biomuta DOID:1324 / lung cancer [ tcga ]
T1410 P1410 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S1432 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y1474 C1474 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S1482 T1482 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]