iPTMnet Report Q13219 PAPPA

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q13219 / PAPP1_HUMAN
Protein Name	Pappalysin-1 precursor
Gene Name	Name: PAPPA
Organism	Homo sapiens (Human)

PRO ID	PR:Q13219 DAG View
PRO Name	pappalysin-1 (human)
Definition	A pappalysin-1 that is encoded in the genome of human.
Short Label	hPAPPA
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q13219 (PAPPA) as Substrate

Q13219

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S100	Phosphorylation		score1	PhosphoSitePlus
	S133	Phosphorylation		score1	PhosphoSitePlus
	Y355	Phosphorylation		score1	IEDB	35494241
	N402	N-Glycosylation		score3	GlyGen UniProt	12421832
	N429	N-Glycosylation		score4	GlyGen UniProt	29741879, 12421832
	K450	Ubiquitination		score1	PhosphoSitePlus
	N480	N-Glycosylation		score3	GlyGen UniProt	12421832
	N601	N-Glycosylation		score3	GlyGen UniProt	12421832
	N619	N-Glycosylation		score3	GlyGen UniProt	12421832
	N725	N-Glycosylation		score3	GlyGen UniProt	12421832
	S917	Phosphorylation		score1	PhosphoSitePlus
	N1026	N-Glycosylation		score3	GlyGen UniProt	12421832
	N1226	N-Glycosylation		score3	GlyGen UniProt	12421832
	N1323	N-Glycosylation		score3	GlyGen UniProt	12421832
	Y1381	Phosphorylation		score1	PhosphoSitePlus
	N1519	N-Glycosylation		score3	GlyGen UniProt	12421832

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
N429	S429	Biomuta		DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S917	I917	Biomuta		DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
N1026	T1026	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]
N1026	K1026	Biomuta		DOID:2531 / hematologic cancer [ cosmic ]
N1323	S1323	Biomuta		DOID:10534 / stomach cancer [ cosmic, icgc ]
Y1381	*	Biomuta		DOID:1324 / lung cancer [ cosmic ]
Y1381	F1381	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]